FB2025_01 , released February 20, 2025
Allele: Dmel\NetBmyc
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General Information
Symbol
Dmel\NetBmyc
Species
D. melanogaster
Name
FlyBase ID
FBal0260875
Feature type
allele
Associated gene
Dmel\NetB
Associated Insertion(s)
TI{TI}NetBmyc
Carried in Construct
Also Known As
NetB-myc, NetrinB-myc, NetBmyc
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gene targeting by homologous recombination
(Brankatschk and Dickson, 2006)
Progenitor genotype
Associated Insertion(s)
TI{TI}NetBmyc
Cytology
Description

A Tag:MYC tag has been inserted at the C-terminal end of NetB.

(Brankatschk and Dickson, 2006)
Allele components
Component
Use(s)
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter or direct label
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage 16
      embryonic/larval dorsal vessel | restricted

      Comment: lumen

      (Asadzadeh et al., 2016)
      Additional Information
      Statement
      Reference

      The secreted NetB market is detected predominantly within the heart lumen in live dissected embryos at late stage 16.

      (Asadzadeh et al., 2016)
       
      Marker for
      Reflects expression of
      NetB
      (Asadzadeh et al., 2016)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A chromosome carrying NetBKI.T:Hsap\MYC and NetAΔ is able to rescue the viability and fertility defects associated with Df(1)NetABΔ. The male courtship behaviour defects are not rescued.

      (Newquist et al., 2013)

      The ventral nerve cord commissures appear normal in NetAΔ, NetBKI.T:Hsap\MYC embryos. Similarly to wild-type, both the EW and EG axons cross the midline in every segment of NetBKI.T:Hsap\MYC, NetBKI.T:SV5\V5,T:Zzzz\TM,T:Hsap\MYC embryos.

      NetAΔ, NetBKI.T:Hsap\MYC animals are viable and fertile with no obvious morphological phenotype.

      Short-range repulsion is preserved in NetAΔ, NetBKI.T:Hsap\MYC embryos that express unc-5Scer\UAS.cKa under the control of Scer\GAL41407, as the ventral nerve cord commissures are completely absent in every segment examined.

      Long-range axon-repulsion is preserved in NetAΔ, NetBKI.T:Hsap\MYC embryos that express unc-5Scer\UAS.cKa under the control of Scer\GAL4ato-NP6558.

      (Brankatschk and Dickson, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      ΔNetBmyc
      (Newquist et al., 2013)
      NetB-myc
      (Kuzina et al., 2011)
      NetBKI.T:Hsap\MYC
      NetBmyc
      (Newquist et al., 2013, Timofeev et al., 2012, Brankatschk and Dickson, 2006)
      NetBmyc
      (Newquist et al., 2013)
      NetrinB-myc
      (Kuzina et al., 2011, Brierley et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)