FB2025_01 , released February 20, 2025
Allele: Dmel\upd1NIG.5993R
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General Information
Symbol
Dmel\upd1NIG.5993R
Species
D. melanogaster
Name
FlyBase ID
FBal0260957
Feature type
allele
Associated gene
Dmel\upd1
Associated Insertion(s)
Carried in Construct
P{NIG.5993R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Copf et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Copf et al., 2011)
Mutagen
in vitro construct
(Copf et al., 2011)
Progenitor genotype
Carried in construct
P{NIG.5993R}
Cytology
Description

UASt regulatory sequences drive expression of an upd1 RNAi construct.

(Copf et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-5993R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of upd1NIG.5993R under the control of either Scer\GAL4tim.PE or Scer\GAL4mir-279.PC results in defects in locomotor activity rhythms (only 21.4% and 42.9% of flies respectively show rhythmic behaviour under constant darkness conditions).

      Expression of upd1NIG.5993R under the control of two copies of Scer\GAL4tim.Scer\UAS results in defects in locomotor activity rhythms (only 42.1% of flies show rhythmic behaviour under constant darkness conditions).

      Expression of upd1NIG.5993R under the control of two copies of Scer\GAL4P2.4.Pdf does not disrupt locomotor activity rhythms.

      (Luo and Sehgal, 2012)

      Expression of upd1NIG.5993R under the control of Scer\GAL4Mef2.247.Switch specifically during the adult stage (in the presence of RU486) causes a defect in long term memory, without affecting anesthesia-resistant memory or short term memory.

      (Copf et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The locomotor rhythm defects seen in mir-279ex117-1 flies under constant darkness conditions are suppressed by expression of upd1NIG.5993R under the control of Scer\GAL4tim.Scer\UAS.

      (Luo and Sehgal, 2012)

      Expression of upd1NIG.5993R does not suppress the increase in circulating lamellocytes seen when ND-75GD6309 is expressed under the control of Scer\GAL4Antp-10.

      (Sinenko et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      osNIG.5993R
      upd1NIG.5993R
      updi-1
      (Cao et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)