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General Information
Symbol
Dmel\TER94UAS.cRa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Ritson
FlyBase ID
FBal0261042
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dVCP wt, UAS-VCP
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of TER94 coding sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
DOES NOT ameliorate  Parkinson's disease
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of TER94Scer\UAS.cRa under the control of Scer\GAL4VGlut-OK371 has no effect on viability. Locomotor behaviour is normal and no defects are seen in neuromuscular junction morphology in third instar larvae.

Expression of TER94Scer\UAS.cRa under the control of Scer\GAL4ey.PH or Scer\GAL4GMR.PF does not have any strong adult eye phenotype.

Expression of TER94Scer\UAS.cRa in the developing eye under the control of Scer\GAL4GMR.PF generates a mild rough eye phenotype but the flies still have a highly organised ommatidial array.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
NOT Enhanced by
NOT suppressed by
Enhancer of
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Enhanced by
NOT Enhanced by
NOT suppressed by
Enhancer of
NOT Enhancer of
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of TER94Scer\UAS.cRa under the control of Scer\GAL4EDTP-DJ694 partially suppresses the thorax indentation phenotype and climbing defects seen in Pink1B9 adults.

The mitochondrial defects seen in the flight muscles of Pink1B9 adults are suppressed by expression of TER94Scer\UAS.cRa under the control of Scer\GAL4EDTP-DJ694.

Expression of TER94Scer\UAS.cRa under the control of Scer\GAL4EDTP-DJ694 enhances the thorax indentation phenotype seen in park25 adults, but has no significant effect on the climbing defect seen in these animals.

The adult eye phenotype (small or rough eyes) characteristic for flies expressing atlScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF or Scer\GAL4ey.PH is exacerbated further by co-expression of TER94Scer\UAS.cRa.

Xenogenetic Interactions
Statement
Reference

Co-expression of TER94Scer\UAS.cRa and Hsap\TARDBPScer\UAS.cRa or Hsap\TARDBPmutNES.Scer\UAS in the developing eye under the control of Scer\GAL4GMR.PF doesn't generate an eye phenotype, indicating there is no interaction between these transgenes.

Co-expression of TER94Scer\UAS.cRa with Hsap\TARDBPmutNLS.Scer\UAS in the developing eye, under the control of Scer\GAL4GMR.PF, resulting in a range of phenotypes, from a mild enhancement of the rough eye phenotype to lethality.

The eye degeneration phenotype found upon expression of TER94R152H.Scer\UAS under the control of Scer\GAL4GMR.PF is strongly enhanced by co-expression of Hsap\TARDBPM337V.Scer\UAS.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
TER94Scer\UAS.cRa
TER94UAS.cRa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Ritson
Secondary FlyBase IDs
    References (6)