Allele Dmel\Mrp4^EP430

General Information
Symbol	Dmel\Mrp4^EP430	Species	D. melanogaster
Name		FlyBase ID	FBal0261060
Feature type	allele	Associated gene	Dmel\Mrp4

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (Kraut et al., 2001, FlyBase, 1996-)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:7,394,744..7,394,744 (FlyBase, 1996-, Kraut et al., 2001, Buff et al., 2007, Mayer et al., 2009, Huang and Haddad, 2007)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{EP}Mrp4[EP430] is inserted 228 bp upstream of the Mrp4 transcription start site and directs over-expression of Mrp4 in the presence of Scer\GAL4. (Huang and Haddad, 2007)
Caused by insertion	P{EP}Mrp4^EP430 (FlyBase, 1996-, Kraut et al., 2001, Buff et al., 2007, Mayer et al., 2009, Huang and Haddad, 2007)
Cytology
Phenotypic Data
Phenotypic Class
	stress response defective, with Scer\GAL4^Act.PU (Huang and Haddad, 2007) stress response defective, with Scer\GAL4^da.G32 (Huang and Haddad, 2007)
Phenotype Manifest In

Detailed Description
	Statement Reference Flies expressing Mrp4[EP3177] using Scer\GAL4[da.G32] or Scer\GAL4[Act.PU] display a profound increase in recovery time after anoxia compared with controls. (Huang and Haddad, 2007)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Selected as: an insertion line that modifies the eye phenotype caused by expression of Ppt1^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF when co-expressed using Scer\GAL4^GMR.PF. (Buff et al., 2007)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG14709^EP430 l(3)S097907^EP430 l(3)S097907a^EP430 Mrp4^EP430
Name Synonym
Secondary FlyBase IDs
	FBal0122962 FBal0157174 FBal0261008
References ( 5 )
Research paper	Mayer et al., 2009, J. Neurosci. 29(11): 3538--3550 Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. [FBrf0207483] Buff et al., 2007, Genetics 176(1): 209--220 Genetic modifiers of Drosophila palmitoyl-protein thioesterase 1-induced degeneration. [FBrf0201672] Huang and Haddad, 2007, Physiol. Genomics 29(3): 260--266 Drosophila dMRP4 regulates responsiveness to O-2 deprivation and development under hypoxia. [FBrf0200983]
Supplementary material	Kraut et al., 2001, Curr. Biol. 11(6): A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. [FBrf0135968]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]

Allele Dmel\Mrp4EP430

Allele Dmel\Mrp4^EP430