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General Information
Symbol
Dmel\seqZ1241
Species
D. melanogaster
Name
FlyBase ID
FBal0261104
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

seqZ1241 homozygotes and seqZ1241/seqC022 mutants exhibit branch bifurcations at the tip of the ganglionic branches. Four to seven ganglionic branches exhibit lumenal bifurcations per embryo at stage 15 and in seven to twelve ganglionic branches per embryo at stage 16. These cells adopt a terminal fate and develop their own terminal lumen, causing the observed luminal bifurcations.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

Removal of one copy of bnl in a bnl00857 heterozygote rescues the ganglionic branch bifurcation phenotype found in seqZ1241 heterozygotes.

Removal of one copy of pnt in a pntΔ88 heterozygote rescues the ganglionic branch bifurcation phenotype found in seqZ1241 heterozygotes.

Expression of Nintra.GS.Scer\UAS under the control of Scer\GAL4btl.PS in seqZ1241 mutant trachea is not sufficient to suppress the ganglionic branch bifurcation phenotype. Activation of N in tracheal cells does not inhibit migration of ganglionic branch cells and is not able to overcome the effects of higher FGF in the ganglionic branches surrounding tissues of seqZ1241 mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of seqScer\UAS.cBa in the ectoderm under the control of Scer\GAL469B rescues the ganglionic branch bifurcation phenotype found in seqZ1241 and seqZ1241/seqC022 mutants.

Expression of seqScer\UAS.cBa in midline precursors and glia of seqZ1241 and seqZ1241/seqC022 mutants under the control of Scer\GAL4sim.PS accomplishes approximately 50% rescue with those embryos that were not fully rescued showing a considerable attenuation of the phenotype.

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Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)