FB2025_05 , released December 11, 2025
Allele: Dmel\lusht.D118A
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General Information
Symbol
Dmel\lusht.D118A
Species
D. melanogaster
Name
FlyBase ID
FBal0261175
Feature type
allele
Associated gene
Dmel\lush
Associated Insertion(s)
Carried in Construct
P{lush.D118A}
Key Links
Transgenic product class
missense_variant
(Ronderos and Smith, 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ronderos and Smith, 2010)
Mutagen
in vitro construct
(Ronderos and Smith, 2010)
Progenitor genotype
lush+tKa
(Ronderos and Smith, 2010)
Carried in construct
P{lush.D118A}
Cytology
Description

A 4.8kb genomic rescue construct containing an amino acid substitution in the lush coding sequence downstream of a lush promoter.

(Ronderos and Smith, 2010)

Amino acid replacement: D118A.

(Ronderos and Smith, 2010)
Allele components
Component
Use(s)
Regulatory region(s)
lush
Encoded product / tool
lush
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Electrophysiological analysis of lusht.D118A flies reveals a significant increase in the basal firing rate of T1 neurons, averaging 200% above wild-type controls. lusht.D118A has no effect on the spontaneous action potential rates of other trichoid neurons.

      Males expressing lusht.D118A exhibit a dramatically reduced courtship behaviour towards wild-type females compared to their wild-type counterparts. Addition of 11-cis-vaccenyl acetate (cVa) to the mating chamber of lusht.D118A males has no additional effect on their courtship.

      Transgenic lusht.D118A females paired with wild-type males are significantly more likely to undertake courtship behavior than their wild-type counterparts.

      (Ronderos and Smith, 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The lusht.D118A-induced activation of T1 neurons is mediated by Or67d as an Or67dGAL4-1 background abolishes this activating effect.

      A Or67dGAL4-1 background completely reverses the lusht.D118A-induced suppression of male courtship, indicating these behavioral changes are mediated through T1 neurons.

      A Or67dGAL4-1 background completely suppresses the increase in courtship behaviour seen in lusht.D118A females.

      (Ronderos and Smith, 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      lushD118A-DS
      (Gomez-Diaz et al., 2013)
      lusht.D118A
      Name Synonyms
      Secondary FlyBase IDs
        References (2)