FlyBase Allele Report: Dmel\CkIIα[GL00003]

General Information

Symbol

Dmel\CkIIα^GL00003

Species

D. melanogaster

Name

FlyBase ID

FBal0262495

Feature type

allele

Associated gene

Dmel\CkIIα

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00003}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00003}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00003

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of schizophrenia

CEA with slgA^UAS.D

(Zwarts et al., 2017)

CEA with slgA^UAS.E

(Zwarts et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

DOES NOT exacerbate schizophrenia

modeled by slgA^UAS.A

(Zwarts et al., 2017)

modeled by slgA^UAS.B

(Zwarts et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | adult stage, with Scer\GAL4^P2.4.Pdf

(Zwarts et al., 2017)

female sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adulthood-only expression of CkIIα^GL00003 under the combined control of Scer\GAL4^P2.4.Pdf and Gal80[ts] (induced by temperature shift from 19[o] to 25[o]C at eclosion) leads to a significant decrease in aggressive behavior, as compared to controls.

(Zwarts et al., 2017)

Females heterozygous for CkIIα^GL00003 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to CkIIα^GL00003 males results in: no eggs; egg/embryonic phenotype: no vitellogenic egg chambers; oogenesis defect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

CkIIα^GL00003, Scer\GAL4^P2.4.Pdf is a non-suppressor of abnormal behavior | adult stage phenotype of Scer\GAL4^P2.4.Pdf, slgA^UAS.A

(Zwarts et al., 2017)

Other

Statement

Reference

CkIIα^GL00003, Scer\GAL4^P2.4.Pdf, slgA^UAS.D has abnormal behavior | adult stage phenotype

(Zwarts et al., 2017)

CkIIα^GL00003, Scer\GAL4^P2.4.Pdf, slgA^UAS.E has abnormal behavior | adult stage phenotype

(Zwarts et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Adulthood-only co-expression of either slgA^UAS.D or slgA^UAS.E in combination with CkIIα^GL00003, under the combined control of Scer\GAL4^P2.4.Pdf and Gal80[ts] and induced by temperature shift from 19[o] to 25[o]C at eclosion, leads to a significant increase in aggressive behavior compared to controls, and contrasts with the decreased aggressive behavior of CkIIα^JF01436 or CkIIα^GL00003 single expressions.

(Zwarts et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

35136