UAS regulatory sequences drive expression of a short inverted repeat.
increased cell death | female limited | nutrition conditional, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
egg chamber | nutrition conditional, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
Expression of Tsc1GL00012 in cardiac muscle under the control of Scer\GAL4GMR88D05 has no effect on pupal eclosion rates.
Expression of Tsc1GL00012 in skeletal muscle under the control of Scer\GAL4how-24B has no effect on pupal eclosion rates.
When expressed with "MTD-GAL4" (which comprises Scer\GAL4nos.PG, Scer\GAL4nos.UTR.T:Hsim\VP16 and Scer\GAL4otu.T:Hsim\VP16) in females that were starved for amino acids, then there is a marked increase in the number of degenerating (apoptotic) young egg chambers, compared to controls.
Scer\GAL4VP16.nos.UTR/Tsc1GL00012 is a suppressor of decreased cell growth phenotype of Wdr241
Scer\GAL4VP16.nos.UTR/Tsc1GL00012 is a suppressor of ovary phenotype of Wdr241
Tsc1GL00012, Scer\GAL4VP16.nos.UTR is a suppressor of ovary phenotype of Akt1HMS00007, Scer\GAL4VP16.nos.UTR
Scer\GAL4nos.PG/Tsc1GL00012 is a suppressor of egg chamber phenotype of mio2/mio1
Scer\GAL4nos.PG/Tsc1GL00012 is a suppressor of egg chamber phenotype of Nup44AΔ15
Scer\GAL4VP16.nos.UTR/Tsc1GL00012 is a non-suppressor of autolysosome phenotype of Wdr241
Expression of Tsc1GL00012 driven by Scer\GAL4nos.UTR.T:Hsim\VP16 significantly suppresses the ovary growth defect but not the inappropriate accumulation of autolysosomes seen in Wdr241/Wdr241 flies.
Co-expression of Tsc1GL00012 rescues the small ovary phenotype resulting from Scer\GAL4nos.UTR.T:Hsim\VP16-mediated expression of Akt1HMS00007.