FlyBase Allele Report: Dmel\PEK[GL00030]

General Information

Symbol

Dmel\PEK^GL00030

Species

D. melanogaster

Name

FlyBase ID

FBal0262521

Feature type

allele

Associated gene

Dmel\PEK

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00030}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00030}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00030

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^UAS.cEa

(Kim et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of PEK^GL00030 under the control of Scer\GAL4^109(2)80 does not significantly affect the total branch length of the dendritic arbor in class IV ddaC neurons in third instar larvae.

(Tsuyama et al., 2017)

Expression of PEK^GL00030 under the control of Scer\GAL4^{elav.Switch.PO} has no effect on climbing ability when flies are raised with RU486.

(Kim et al., 2014)

Females heterozygous for PEK^GL00030 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to PEK^GL00030 males results in: 80% hatching; non-maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

PEK^GL00030, Scer\GAL4^hh.PU is a suppressor | partially of increased cell death | larval stage phenotype of Paip1^GD13792, Scer\GAL4^hh.PU

(Xue et al., 2023)

PEK^GL00030, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

PEK^GL00030, Scer\GAL4^109(2)80 is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

PEK^GL00030, Scer\GAL4^{elav.Switch.PO} is a suppressor | partially of abnormal locomotor behavior | adult stage | RU486 conditional phenotype of Hsap\TARDBP^UAS.cEa, Scer\GAL4^{elav.Switch.PO}

(Kim et al., 2014)

PEK^GL00030, Scer\GAL4^unspecified is a suppressor of increased cell growth rate | somatic clone | third instar larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^unspecified

(Nagy et al., 2013)

PEK^GL00030, Scer\GAL4^ptc-559.1 is a suppressor of abnormal size | third instar larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^ptc-559.1

(Nagy et al., 2013)

PEK^GL00030, Scer\GAL4^ptc-559.1 is a suppressor of abnormal size phenotype of Myc^UAS.cZa, Scer\GAL4^ptc-559.1

(Nagy et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

PEK^GL00030, Scer\GAL4^hh.PU is a suppressor | partially of wing disc posterior compartment | larval stage phenotype of Paip1^GD13792, Scer\GAL4^hh.PU

(Xue et al., 2023)

PEK^GL00030, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

PEK^GL00030, Scer\GAL4^109(2)80 is a suppressor | partially of abdominal dorsal multidendritic neuron ddaC | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

PEK^GL00030, Scer\GAL4^109(2)80 is a suppressor | partially of dendrite | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

PEK^GL00030, Scer\GAL4^unspecified is a suppressor of embryonic/larval fat body | somatic clone | third instar larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^unspecified

(Nagy et al., 2013)

PEK^GL00030, Scer\GAL4^ptc-559.1 is a suppressor of first basal wing cell phenotype of Myc^UAS.cZa, Scer\GAL4^ptc-559.1

(Nagy et al., 2013)

PEK^GL00030, Scer\GAL4^ptc-559.1 is a suppressor of wing disc | third instar larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^ptc-559.1

(Nagy et al., 2013)

PEK^GL00030, Scer\GAL4^ptc-559.1 is a suppressor of first posterior wing cell phenotype of Myc^UAS.cZa, Scer\GAL4^ptc-559.1

(Nagy et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The shortening of the dendritic arbor in class IV ddaC neurons in third instar larvae expressing prel^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^109(2)80 is strongly mitigated by co-expression of PEK[GL00030].

(Tsuyama et al., 2017)

Xenogenetic Interactions

Statement

Reference

Expression of PEK^GL00030 greatly suppresses the reduction in climbing ability seen when Hsap\TARDBP^Scer\UAS.cEa is expressed under the control of Scer\GAL4^{elav.Switch.PO} and the flies are raised with RU486.

(Kim et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

35162

y¹ sc^* v¹ sev²¹; P{TRiP.GL00030}attP2

NIG-Fly

GL00030