FB2019_05, released Oct 15, 2019

Allele: Dmel\ballGL00068

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General Information
Symbol
Dmel\ballGL00068
Species
D. melanogaster
Name
FlyBase ID
FBal0262555
Feature type
allele
Associated gene
Dmel\ball
Associated Insertion(s)
Carried in Construct
P{TRiP.GL00068}
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - RNAi
(Ni et al., 2011.7.19)
in vitro construct - regulatory fusion
(Ni et al., 2011.7.19)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{TRiP.GL00068}
      Cytology
      Nature of the lesion
      Statement
      Reference
      UAS regulatory sequences drive expression of a short inverted repeat.
      (Ni et al., 2011.7.19)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      ball
      Also carries
      loxP
      Associated Sequence Features
      dsRNA-GL00068
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      Expression of ballGL00068 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in severe condensation defects (amorphous or undercondensed chromosomes with compromised attachment between sister chromatids) and failure to assemble spindle microtubules in mature oocytes and severe disruption of karyosome (compact body of condensed meiotic chromosome) formation during prophase I in stage 12 or 13 maturing oocytes.
      (Nikalayevich and Ohkura, 2015)
      Females heterozygous for ballGL00068 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to ballGL00068 males results in: no eggs; egg/embryonic phenotype: no vitellogenic egg chambers; oogenesis defect.
      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      The severe condensation defects resulting in amorphous or undercondensed chromosomes in mature oocytes characteristic for flies expressing ballGL00068 RNAi under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 are significantly ameliorated by co-expression of bafHMS00195 RNAi.
      (Nikalayevich and Ohkura, 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ballGL00068
      Name Synonyms
      Secondary FlyBase IDs
        References (3)