FB2025_01 , released February 20, 2025
Allele: Dmel\Coq8GL00260
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General Information
Symbol
Dmel\Coq8GL00260
Species
D. melanogaster
Name
FlyBase ID
FBal0262730
Feature type
allele
Associated gene
Dmel\Coq8
Associated Insertion(s)
Carried in Construct
P{TRiP.GL00260}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.GL00260}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-GL00260
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  primary coenzyme Q10 deficiency 4
      CEC
      (Zhu et al., 2017)
      model of  nephrotic syndrome
      CEA
      (Zhu et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      FlyBase curator comment: 'coenzyme Q10 deficiency disease' subtype 'primary coenzyme Q10 deficiency 4' is associated with gene COQ8. Coq8GL00260, when driven in pericardial nephrocytes (Scer\GAL4Ugt36A1.PK) serves to model the nephrotic syndrome phenotype of 'primary coenzyme Q10 deficiency 4'.

      (Zhu et al., 2017)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult flies expressing CG32649GL00260 under the control of Scer\GAL4Dot.PK display nephrocyte functional defects (measured by uptake assays) but their adult lifespan is comparable to controls.

      (Fu et al., 2017)

      Females heterozygous for CG32649GL00260 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to CG32649GL00260 males results in: 85% hatching; non-maternal effect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG32649GL00260
      Coq8GL00260
      Name Synonyms
      Secondary FlyBase IDs
        References (4)