FB2019_05, released Oct 15, 2019

Allele: Dmel\sggGL00277

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General Information
Symbol
Dmel\sggGL00277
Species
D. melanogaster
Name
FlyBase ID
FBal0262746
Feature type
allele
Associated gene
Dmel\sgg
Associated Insertion(s)
Carried in Construct
P{TRiP.GL00277}
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - RNAi
(Ni et al., 2011.7.19)
in vitro construct - regulatory fusion
(Ni et al., 2011.7.19)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{TRiP.GL00277}
      Cytology
      Nature of the lesion
      Statement
      Reference
      UAS regulatory sequences drive expression of a short inverted repeat.
      (Ni et al., 2011.7.19)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      sgg
      Also carries
      loxP
      Associated Sequence Features
      dsRNA-GL00277
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      DOES NOT ameliorate  Alzheimer's disease
      modeled by Hsap\MAPTUAS.cWa
      (Ando et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      Adults expressing sggGL00277 under the control of Scer\GAL4GMR.PF present eye sizes comparable to controls.
      (Ando et al., 2016)
      Females heterozygous for sggGL00277 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to sggGL00277 males results in: 0% hatching; egg/embryonic phenotype: "small eggs, all empty"; maternal effect.
      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Adults co-expressing Hsap\APPAβ42.Scer\UAS.T:Rnor\SS-PENK and sggGL00277 under the control of Scer\GAL4GMR.PF have eye sizes comparable to controls. The small eyes observed upon expression of Hsap\MAPTScer\UAS.cWa driven by Scer\GAL4GMR.PF is enhanced by the co-expression of Hsap\APPAβ42.Scer\UAS.T:Rnor\SS-PENK alone; this enhancement is not suppressed by also co-expressing sgg[GL00277]. The small eyes observed upon expression of Hsap\MAPTScer\UAS.cWa driven by Scer\GAL4GMR.PF are not suppressed by co-expression of sgg[GL00277].
      (Ando et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sggGL00277
      Name Synonyms
      Secondary FlyBase IDs
        References (4)