FlyBase Allele Report: Dmel\Rga[GL00386]

General Information

Symbol

Dmel\Rga^GL00386

Species

D. melanogaster

Name

FlyBase ID

FBal0262852

Feature type

allele

Associated gene

Dmel\Rga

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00386}

Also Known As

Rga RNAi, GL00386

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00386}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00386

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with Delta^UAS.cDa

(Vicente et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^en.PU

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

wing vein, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing vein, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Detailed Description

Statement

Reference

Expression of Rga^GL00386 under the control of either Scer\GAL4^nub.PK or Scer\GAL4^en.PU results in ectopic and disrupted wing veins. Scer\GAL4^Act5C.PI-driven expression is lethal; no overt adult phenotype is observed with either Scer\GAL4^ey.PH or Scer\GAL4^GMR.PF.

(Dietz et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Rga^GL00386, Scer\GAL4^en.PU has visible | adult stage phenotype, enhanceable by htt^int

(Dietz et al., 2015)

Rga^GL00386, Scer\GAL4^nub.PK has visible | adult stage phenotype, enhanceable by htt^GD14943, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Rga^GL00386, Scer\GAL4^en.PU has visible | adult stage phenotype, enhanceable by htt^GD14943, Scer\GAL4^en.PU

(Dietz et al., 2015)

Enhancer of

Statement

Reference

Rga^GL00386, Scer\GAL4^ey.PH is an enhancer of neoplasia | adult stage phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Rga^GL00386, Scer\GAL4^ey.PH is an enhancer of visible | adult stage phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

Rga^GL00386, Scer\GAL4^en.PU has wing vein phenotype, enhanceable by htt^int

(Dietz et al., 2015)

Rga^GL00386, Scer\GAL4^nub.PK has wing vein phenotype, enhanceable by htt^GD14943, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Rga^GL00386, Scer\GAL4^en.PU has wing vein phenotype, enhanceable by htt^GD14943, Scer\GAL4^en.PU

(Dietz et al., 2015)

Enhancer of

Statement

Reference

Rga^GL00386, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The adult wing phenotype induced by expression of Rga^GL00386 under the control of either Scer\GAL4^en.PU or Scer\GAL4^nub.PK is enhanced by co-expression of htt^GD14943 and the phenotype observed with the Scer\GAL4^en.PU driver is also enhanced by combination with a single copy of htt^int.

(Dietz et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

35460