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General Information
Symbol
Dmel\lidGLV21071
Species
D. melanogaster
Name
FlyBase ID
FBal0263052
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of lidGLV21071 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in premature transcriptional reactivation as well as precocious and aberrant karyosome remodeling (the oocytes display early increase in chromatin openness and overly developed chromatin protrusions compared to controls) in prophase I-arrested oocytes (this however is not due to the incapability of the oocytes to enter transcriptional quiescence or to compact their chromosomes into karyosome in the first place). The metaphase I arrest of mature oocytes is not affected. Expression of lidGLV21071 compromises meiotic completion as illustrated by defects in polar body integrity (scattered chromatin, abnormal chromosome condensation) and the eggs (though normal in size and dorsal-ventral patterning) largely fail to enter embryogenesis after fertilization resulting in strongly reduced female fertility.

Expression of lidGLV21071 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in female germlines results in sterility and abnormal morphology of the karyosome in most oocytes; a centromere clustering defect in the germaria wherein cohesion of sister chromosomes is maintained, but pairing of homologous pericentromeric regions of chromosomes 2 and 3 is disrupted; defects in the assembly and/or maintenance of the synaptonemal complex; defects in chromosome positioning and orientation in metaphase I oocytes; but does not cause significantly different numbers of DNA double stranded breaks in the germaria, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
NOT suppressed by
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of Su(var)3-3HMS00638 does not enhance or suppress the defective karyosome morphology seen in flies expressing lidGLV21071 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

lokp6/+ fails to suppress the abnormal karyosome morphology observed in females expressing lidGLV21071 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

Co-expression of p53GL01220 fails to suppress the abnormal karyosome morphology observed in females expressing lidGLV21071 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
lidGLV21071
Name Synonyms
Secondary FlyBase IDs
    References (3)