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General Information
Symbol
Dmel\ykiHMS00041
Species
D. melanogaster
Name
FlyBase ID
FBal0263077
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-yki-RNAi, UAS-ykiRNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
DOES NOT ameliorate  cancer
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Somatic clones expressing ykiHMS00041 under the control of Scer\GAL4Tub.PU contain a similar overall number of cells and intestinal stem cells in adult flies as controls, but show a reduction in the ratio of stem cells/clone.

Third instar larvae expressing ykiHMS00041 under the control of Scer\GAL4repo.PU exhibit fewer glial nuclei along peripheral nerves, where no bulges are observed, as compared to controls.

Expression of ykiHMS00041 under the control of Scer\GAL4Myo31DF-NP0001 partially inhibits the increase in midgut precursor cells seen in flies treated with dextran sulfate sodium (DSS).

Expression of ykiHMS00041 in the adult midgut under the control of Scer\GAL4esg-NP5130 and Scer\GAL80ts.αTub84B has no effect on cell proliferation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Suppressed by
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Co-expressing ykiHMS00041 and bskDN.UAS under the control of Scer\GAL4dpp.blk1 does not have a major effect in the wing disc.

Third instar larval eye-antennal imaginal disc clones co-expressing dlg1GD4689 and Ras85DV12.Scer\UAS under the control of Scer\GAL4Act5C.CoinFLP-FRT, in combination with Dicer-2 for efficient RNAi, form invasive tumors and induce autophagosomes (assessed by a Atg8a fluorescence reporter) in a cell non-autonomous manner in neighboring disc tissue, both of which are significantly suppressed by the additional clonal co-expression of ykiHMS00041.

Expression of ykiHMS00041 suppresses the increase in esg-positive cells and mitosis seen when TaoGD8262 is expressed in adult midguts under the control of Scer\GAL4esg-NP5130 and Scer\GAL80ts.αTub84B.

Expression of ykiHMS00041 suppresses the increase in esg-positive cells and mitosis seen when TaodsRNA.shRNA.Scer\UAS is expressed in adult midguts under the control of Scer\GAL4esg-NP5130 and Scer\GAL80ts.αTub84B.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
ykiHMS00041
Name Synonyms
Secondary FlyBase IDs
    References (16)