FlyBase Allele Report: Dmel\yki[HMS00041]

General Information

Symbol

Dmel\yki^HMS00041

Species

D. melanogaster

Name

FlyBase ID

FBal0263077

Feature type

allele

Associated gene

Dmel\yki

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00041}

Also Known As

UAS-yki-RNAi, UAS-yki^RNAi, yki-RNAi, UAS.Yki-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00041}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00041

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by dlg1^GD4689, Ras85D^V12.UAS

(Katheder et al., 2017)

ameliorates high grade glioma

modeled by Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS

(Gangwani et al., 2020)

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Vigneswaran et al., 2021)

DOES NOT ameliorate cancer

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage | somatic clone - tissue specific, with Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

lethal, with Scer\GAL4^en-e16E

(Tyra et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

Somatic clones expressing yki^HMS00041 under the control of Scer\GAL4^Tub.PU contain a similar overall number of cells and intestinal stem cells in adult flies as controls, but show a reduction in the ratio of stem cells/clone.

(Gervais et al., 2019)

Third instar larvae expressing yki^HMS00041 under the control of Scer\GAL4^repo.PU exhibit fewer glial nuclei along peripheral nerves, where no bulges are observed, as compared to controls.

(Zülbahar et al., 2018)

Expression of yki^HMS00041 under the control of Scer\GAL4^{Myo31DF-NP0001} partially inhibits the increase in midgut precursor cells seen in flies treated with dextran sulfate sodium (DSS).

(Huang et al., 2014)

Expression of yki^HMS00041 in the adult midgut under the control of Scer\GAL4^esg-NP5130 and Scer\GAL80^ts.αTub84B has no effect on cell proliferation.

(Huang et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, yki^HMS00041 has increased mortality during development phenotype, suppressible | partially by Atg1^GD7149, Scer\GAL4^en-e16E

(Tyra et al., 2020)

Scer\GAL4^repo.PU, yki^HMS00041 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by Ntan1^KK107726, Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

NOT Enhancer of

Statement

Reference

yki^HMS00041, Scer\GAL4^Act5C.PI is a non-enhancer of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Suppressor of

Statement

Reference

yki^HMS00041, Scer\GAL4^esg.PU is a suppressor of increased cell number | adult stage phenotype of EMC3^GD1074, Scer\GAL4^esg.PU

(Shi et al., 2023)

yki^HMS00041/Scer\GAL4^unspecified is a suppressor of increased size | somatic clone phenotype of EMC3^e02662

(Shi et al., 2023)

yki^HMS00041/Scer\GAL4^unspecified is a suppressor of increased size | somatic clone phenotype of EMC1^BG02000

(Shi et al., 2023)

yki^HMS00041, Scer\GAL4^NP0001 is a suppressor of increased occurrence of cell division | adult stage phenotype of Rab21^GD9402, Scer\GAL4^NP0001

(Nassari et al., 2022)

yki^HMS00041, Scer\GAL4^NP0001 is a suppressor of increased cell death | adult stage phenotype of Rab21^GD9402, Scer\GAL4^NP0001

(Nassari et al., 2022)

yki^HMS00041, Scer\GAL4^NP0001 is a suppressor of increased occurrence of cell division | adult stage phenotype of Rab21^KK115582, Scer\GAL4^NP0001

(Nassari et al., 2022)

yki^HMS00041, Scer\GAL4^NP0001 is a suppressor of increased cell death | adult stage phenotype of Rab21^KK115582, Scer\GAL4^NP0001

(Nassari et al., 2022)

yki^HMS00041, Scer\GAL4^repo.PU is a suppressor of increased cell number | third instar larval stage phenotype of Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

yki^HMS00041/Tep1^HMS00641, Scer\GAL4^repo.PU is a suppressor of increased cell number | third instar larval stage phenotype of Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

yki^HMS00041, Scer\GAL4^repo.PU is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

yki^HMS00041, Scer\GAL4^repo.PU is a suppressor | partially of neoplasia | third instar larval stage phenotype of Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

yki^HMS00041/Tep1^HMS00641, Scer\GAL4^repo.PU is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

yki^HMS00041/Tep1^HMS00641, Scer\GAL4^repo.PU is a suppressor | partially of neoplasia | third instar larval stage phenotype of Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

yki^HMS00041/Scer\GAL4^Tub.PU is a suppressor of increased cell number | recessive | somatic clone | adult stage phenotype of kis^10D26

(Gervais et al., 2019)

yki^HMS00041, Scer\GAL4^dpp.blk1 is a suppressor | partially of neoplasia phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

yki^HMS00041/bsk^DN.UAS, Scer\GAL4^dpp.blk1 is a suppressor of neoplasia phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

yki^HMS00041/bsk^DN.UAS, Scer\GAL4^dpp.blk1 is a suppressor of abnormal cell migration | larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

yki^HMS00041, Scer\GAL4^repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage | third instar larval stage phenotype of Ntan1^KK107726, Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

yki^HMS00041, Scer\GAL4^{Act5C.CoinFLP-FRT} is a suppressor | somatic clone of neoplasia | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689

(Katheder et al., 2017)

yki^HMS00041, Scer\GAL4^{Act5C.CoinFLP-FRT} is a suppressor | somatic clone of abnormal size | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689

(Katheder et al., 2017)

NOT Suppressor of

Statement

Reference

yki^HMS00041, Scer\GAL4^Act5C.PI is a non-suppressor of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki^HMS00041, Scer\GAL4^dpp.blk1 is a non-suppressor of abnormal cell migration | larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^repo.PU, yki^HMS00041 has PNS glial cell | third instar larval stage phenotype, suppressible | partially by Ntan1^KK107726, Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

Scer\GAL4^repo.PU, yki^HMS00041 has abdominal nerve | third instar larval stage phenotype, suppressible | partially by Ntan1^KK107726, Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

NOT Enhancer of

Statement

Reference

yki^HMS00041, Scer\GAL4^Act5C.PI is a non-enhancer of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki^HMS00041, Scer\GAL4^Act5C.PI is a non-enhancer of developing neuron | larval stage | decreased number | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Suppressor of

Statement

Reference

yki^HMS00041, Scer\GAL4^esg.PU is a suppressor of adult midgut phenotype of EMC3^GD1074, Scer\GAL4^esg.PU

(Shi et al., 2023)

yki^HMS00041/Scer\GAL4^unspecified is a suppressor of adult midgut | somatic clone phenotype of EMC3^e02662

(Shi et al., 2023)

yki^HMS00041/Scer\GAL4^unspecified is a suppressor of adult midgut | somatic clone phenotype of EMC1^BG02000

(Shi et al., 2023)

yki^HMS00041, Scer\GAL4^NP0001 is a suppressor of adult gut phenotype of Rab21^GD9402, Scer\GAL4^NP0001

(Nassari et al., 2022)

yki^HMS00041, Scer\GAL4^NP0001 is a suppressor of adult gut phenotype of Rab21^KK115582, Scer\GAL4^NP0001

(Nassari et al., 2022)

yki^HMS00041, Scer\GAL4^repo.PU is a suppressor of neuroblast | increased number | third instar larval stage phenotype of Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

yki^HMS00041/Tep1^HMS00641, Scer\GAL4^repo.PU is a suppressor of neuroblast | increased number | third instar larval stage phenotype of Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

yki^HMS00041/Scer\GAL4^Tub.PU is a suppressor of adult midgut epithelium | somatic clone phenotype of kis^10D26

(Gervais et al., 2019)

yki^HMS00041/Scer\GAL4^Tub.PU is a suppressor of intestinal stem cell | somatic clone | adult stage phenotype of kis^10D26

(Gervais et al., 2019)

yki^HMS00041, Scer\GAL4^dpp.blk1 is a suppressor | partially of wing disc phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

yki^HMS00041/bsk^DN.UAS, Scer\GAL4^dpp.blk1 is a suppressor of wing disc phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

yki^HMS00041, Scer\GAL4^repo.PU is a suppressor of PNS glial cell | third instar larval stage phenotype of Ntan1^KK107726, Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

yki^HMS00041, Scer\GAL4^repo.PU is a suppressor of abdominal nerve | third instar larval stage phenotype of Ntan1^KK107726, Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

yki^HMS00041, Scer\GAL4^{Act5C.CoinFLP-FRT} is a suppressor | cell non-autonomous | somatic clone of autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689

(Katheder et al., 2017)

yki^HMS00041, Scer\GAL4^{Act5C.CoinFLP-FRT} is a suppressor | cell non-autonomous | somatic clone of eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689

(Katheder et al., 2017)

yki^HMS00041/Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B is a suppressor of adult midgut phenotype of Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B, Tao^GD8262

(Huang et al., 2014)

yki^HMS00041/Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B is a suppressor of adult midgut phenotype of Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B, Tao^RNAi.UAS.cHa

(Huang et al., 2014)

NOT Suppressor of

Statement

Reference

yki^HMS00041, Scer\GAL4^Act5C.PI is a non-suppressor of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki^HMS00041, Scer\GAL4^Act5C.PI is a non-suppressor of developing neuron | larval stage | decreased number | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expressing yki^HMS00041 and bsk^DN.UAS under the control of Scer\GAL4^dpp.blk1 does not have a major effect in the wing disc.

(Blaquiere et al., 2018)

Third instar larval eye-antennal imaginal disc clones co-expressing dlg1^GD4689 and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^{Act5C.CoinFLP-FRT}, in combination with Dicer-2 for efficient RNAi, form invasive tumors and induce autophagosomes (assessed by a Atg8a fluorescence reporter) in a cell non-autonomous manner in neighboring disc tissue, both of which are significantly suppressed by the additional clonal co-expression of yki^HMS00041.

(Katheder et al., 2017)

Expression of yki^HMS00041 suppresses the increase in esg-positive cells and mitosis seen when Tao^GD8262 is expressed in adult midguts under the control of Scer\GAL4^esg-NP5130 and Scer\GAL80^ts.αTub84B.

Expression of yki^HMS00041 suppresses the increase in esg-positive cells and mitosis seen when Tao^{dsRNA.shRNA.Scer\UAS} is expressed in adult midguts under the control of Scer\GAL4^esg-NP5130 and Scer\GAL80^ts.αTub84B.

(Huang et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34067

y¹ v¹; P{TRiP.HMS00041}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

yki^HMS00041

(Forest et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (32)

Report Sections

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