FB2025_02 , released April 17, 2025
Allele: Dmel\brmHMS00050
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General Information
Symbol
Dmel\brmHMS00050
Species
D. melanogaster
Name
FlyBase ID
FBal0263079
Feature type
allele
Associated gene
Dmel\brm
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS00050}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.HMS00050}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS00050
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of brmHMS00050 (together with UAS-Dicer2 to enhance RNAi efficiency) in somatic (flip-out) clones under the control of Scer\GAL4Act.PU results in increased levels of apoptosis in the wing pouch of third instar larval wing disc.

      (Xie et al., 2017)

      Expression of brmHMS00050 under the control of Scer\GAL4bbg-C96 does not result in any obvious wing phenotype.

      (Ellis et al., 2015)

      Expression of brmHMS00050 under the control of Scer\GAL4SPARC-MI00329-GAL4 results in melanisation of the fat body.

      (Zang et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Scer\GAL4bbg-C96/brmHMS00050 is an enhancer of visible phenotype of Scer\GAL4bbg-C96, domRNAi.Sym.UAS

      (Ellis et al., 2015)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Scer\GAL4bbg-C96/brmHMS00050 is an enhancer of wing phenotype of Scer\GAL4bbg-C96, domRNAi.Sym.UAS

      (Ellis et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of brmHMS00050 enhances the wing nicking phenotype of flies expressing domdsRNA.Sym.Scer\UAS under the control of Scer\GAL4bbg-C96.

      (Ellis et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference

      Simultaneous expression of brmHMS00050 and BacA\p35Scer\UAS.cHa under the control of Scer\GAL4Act.PU in somatic (flip-out) clones in third instar larval wing discs does not cause any obvious overgrowth.

      (Xie et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      brmHMS00050
      Name Synonyms
      Secondary FlyBase IDs
        References (10)