FlyBase Allele Report: Dmel\Rab5[HMS00147]

General Information

Symbol

Dmel\Rab5^HMS00147

Species

D. melanogaster

Name

FlyBase ID

FBal0263144

Feature type

allele

Associated gene

Dmel\Rab5

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00147}

Also Known As

Rab5^RNAi, HMS00147

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - RNAi

(Ni et al., 2011.7.19)

in vitro construct - regulatory fusion

(Ni et al., 2011.7.19)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{TRiP.HMS00147}

Cytology

Nature of the lesion

Statement

Reference

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Rab5

Also carries

loxP

recombinase target site

Associated Sequence Features

dsRNA-HMS00147

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Hsim\VP16^AD.nrv2, Scer\GAL4^{DBD.wrapper.932i}

(Coutinho-Budd et al., 2017)

melanotic mass phenotype, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

Phenotype Manifest In

embryonic/larval cell body glial cell | third instar larval stage, with Hsim\VP16^AD.nrv2, Scer\GAL4^{DBD.wrapper.932i}

(Coutinho-Budd et al., 2017)

fat body, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

melanotic mass, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

Detailed Description

Statement

Reference

Expression of Rab5^HMS00147 under the control of CtxGlia-SplitGal4 (Hsim\VP16^AD.nrv2 and Scer\GAL4^{DBD.wrapper.932i}) leads to an altered cortex glial morphology in third instar larvae when compared to controls.

(Coutinho-Budd et al., 2017)

Expression of Rab5^HMS00147 under the control of Scer\GAL4^{SPARC-MI00329-GAL4} results in melanisation of the fat body.

(Zang et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Rab5^HMS00147, Scer\GAL4^ptc.PU is a non-suppressor of lethal - all die before end of P-stage phenotype of Hsap\KIF5B::Hsap\RET^UAS.cDa, Scer\GAL4^ptc.PU

(Das and Cagan, 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Rab5^HMS00147, Scer\GAL4^Cg.PA is a suppressor of fat cell | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Rab5^HMS00147, Scer\GAL4^Cg.PA is a suppressor of endoplasmic reticulum | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Rab5^HMS00147, Scer\GAL4^Cg.PA is a suppressor of nucleus | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34832

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00147}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rab5^HMS00147

Rab5^RNAi

(Weiss et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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