FlyBase Allele Report: Dmel\caz[HMS00156]

General Information

Symbol

Dmel\caz^HMS00156

Species

D. melanogaster

Name

FlyBase ID

FBal0263152

Feature type

allele

Associated gene

Dmel\caz

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00156}

Also Known As

UAS-Caz^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00156}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00156

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^Δ166, Vap33^P58S.cRa.UAS

(Tendulkar et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Machamer et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of caz^HMS00156 under the control of Scer\GAL4^nSyb.PU does not cause developmental lethality.

(Frickenhaus et al., 2015)

Expression of caz^HMS00156 in motor neurons under the control of Scer\GAL4^VGlut-OK371 causes an approximately 20% increase in evoked excitatory junction potential (EJP) amplitude compared with control. This increase in EJP amplitude is due to an approximately 25% increase in mEJP amplitude without any significant change in quantal content.

(Machamer et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions