FlyBase Allele Report: Dmel\dlg1[HMS00172]

General Information

Symbol

Dmel\dlg1^HMS00172

Species

D. melanogaster

Name

FlyBase ID

FBal0263167

Feature type

allele

Associated gene

Dmel\dlg1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00172}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00172}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00172

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA

(Bunker et al., 2015)

model of carcinoma

CEA with Ras85D^V12.cUa.UAS

(Toggweiler et al., 2016)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

neoplasia | third instar larval stage

(Bunker et al., 2015)

Phenotype Manifest In

garland cell, with Scer\GAL4^sns.PK

(Heiden et al., 2021)

wing disc | third instar larval stage

(Bunker et al., 2015)

Detailed Description

Statement

Reference

The expression of dlg1^HMS00172 driven by Scer\GAL4^Bx-MS1096 leads to the formation of large tumors in the third instar larval wing disc.

(Bunker et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible by dlg1^{Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible by dlg1^{Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has decreased size | adult stage phenotype, suppressible by dlg1^{Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible by dlg1^{Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible by dlg1^{ΔPDZ.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible by dlg1^{KR6Q.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible | partially by dlg1^{m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible | partially by dlg1^{ΔGUK.m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible | partially by dlg1^{ΔGUK.m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible | partially by dlg1^{ΔPDZ.m30.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible | partially by dlg1^{ΔGUK.m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible by dlg1^{ΔPDZ.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible by dlg1^{ΔPDZ.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible by dlg1^{S4A.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible by dlg1^{S4A.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible by dlg1^{ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible by dlg1^{ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible by dlg1^{ΔPDZ.S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible by dlg1^{ΔPDZ.S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

NOT suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has decreased size | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{KR6Q.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{KR6Q.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.m30.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.m30.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{S4A.ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{S4A.ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has partially lethal - majority die phenotype, non-suppressible by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has partially lethal - majority die phenotype

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has some die during P-stage phenotype

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has some die during larval stage phenotype

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has decreased size | adult stage phenotype

(Lu et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible by dlg1^{Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible | partially by dlg1^{ΔGUK.m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible by dlg1^{ΔPDZ.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible by dlg1^{S4A.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible by dlg1^{ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible by dlg1^{ΔPDZ.S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

NOT suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{KR6Q.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{ΔPDZ.m30.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{ΔPDZ.KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{S4A.ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype

(Lu et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34854

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00172}attP2/TM3, Sb¹

NIG-Fly

HMS00172

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00172}attP2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dlg1^HMS00172

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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