FB2025_01 , released February 20, 2025
Allele: Dmel\Cdk9HMS01391
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General Information
Symbol
Dmel\Cdk9HMS01391
Species
D. melanogaster
Name
FlyBase ID
FBal0263301
Feature type
allele
Associated gene
Dmel\Cdk9
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01391}
Also Known As
HMS01391, UAS-CDK9-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.HMS01391}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS01391
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos from mothers expressing Cdk9HMS01391 under the control of Scer\GAL4VP16.mat.αTub67C show posterior-specific loss of cells in embryos prior to gastrulation, from abnormal loss of posterior nuclei from the cortex prior to germ-band extension; the mesoderm show defects in cell shape as well as multinucleated cells. Germ band extension does not proceed normally and gastrulation is delayed.

      (Dahlberg et al., 2015)

      Females heterozygous for Cdk9HMS01391 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to Cdk9HMS01391 males results in: "few eggs,38% hatching"; egg/embryonic phenotype: "U-shaped, segmentation defects"; maternal effect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Cdk9HMS01391
      Name Synonyms
      Secondary FlyBase IDs
        References (6)