FlyBase Allele Report: Dmel\scrib[HMS01490]

General Information

Symbol

Dmel\scrib^HMS01490

Species

D. melanogaster

Name

FlyBase ID

FBal0263398

Feature type

allele

Associated gene

Dmel\scrib

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01490}

Also Known As

scrib RNAi, UAS-scrib RNAi, UAS-Scrib^RNAi, UAS-scrib-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS01490}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01490

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA

(Kumar and Srikrishna, 2025, Bunker et al., 2015)

model of carcinoma

CEA

(Yadav and Srikrishna, 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cancer

is ameliorated by Socs36E^UASp.cCa

(Bunker et al., 2015)

is ameliorated by dome^ΔCYT.UAS

(Bunker et al., 2015)

is exacerbated by hep^Act.UAS

(Kumar and Srikrishna, 2025)

is ameliorated by hep^NIG.2190R

(Kumar and Srikrishna, 2025)

model of carcinoma

is ameliorated by park^{UAS.Tag:FLAG,Tag:Mito(hCOX4I1)}

(Yadav and Srikrishna, 2019)

is exacerbated by park^JF01200

(Yadav and Srikrishna, 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | larval stage, with Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

increased size | larval stage, with Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

neoplasia | larval stage, with Scer\GAL4^ptc-559.1

(Huang et al., 2023)

neoplasia | larval stage, with Scer\GAL4^ptc-559.1, scrib⁶⁷³

(Huang et al., 2023)

neoplasia | third instar larval stage, with Scer\GAL4^Bx-MS1096

(Bunker et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Maternal expression of scrib^HMS01490 under the control of Scer\GAL4^{VP16.mat.αTub67C} leads to embryos showing epithelial/cuticular defects, namely epidermal cell clusters surrounded by cuticle.

(Silver et al., 2019)

The expression of scrib^HMS01490 driven by Scer\GAL4^Bx-MS1096 leads to the formation of large tumors in the third instar larval wing disc.

(Bunker et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^ptc-559.1, scrib^HMS01490 has increased cell death | larval stage phenotype, non-enhanceable by Iswi^HMS00628, Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

Scer\GAL4^ptc-559.1, scrib^HMS01490 has increased cell death | larval stage phenotype, non-enhanceable by E(bx)^HMS00065, Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

Suppressed by

Statement

Reference

Scer\GAL4^ptc-559.1, scrib^HMS01490 has neoplasia | larval stage phenotype, suppressible by Scer\GAL4^ptc-559.1/wts^UAS.Tag:MYC

(Huang et al., 2023)

Scer\GAL4^ptc-559.1, scrib^HMS01490 has neoplasia | larval stage phenotype, suppressible by Scer\GAL4^ptc-559.1/kune::α-Cat^UAS.Tag:MYC

(Huang et al., 2023)

Scer\GAL4^Bx-MS1096, scrib^HMS01490 has neoplasia | third instar larval stage phenotype, suppressible by Socs36E^UASp.cCa/Scer\GAL4^Bx-MS1096

(Bunker et al., 2015)

Scer\GAL4^Bx-MS1096, scrib^HMS01490 has neoplasia | third instar larval stage phenotype, suppressible by dome^ΔCYT.UAS/Scer\GAL4^Bx-MS1096

(Bunker et al., 2015)

NOT suppressed by

Statement

Reference

Scer\GAL4^ptc-559.1, scrib^HMS01490 has neoplasia | larval stage phenotype, non-suppressible by Scer\GAL4^ptc-559.1/shg::α-Cat^{dCyt.UAS.Tag:MYC}

(Huang et al., 2023)

Scer\GAL4^ptc-559.1, scrib^HMS01490 has increased size | larval stage phenotype, non-suppressible by Iswi^HMS00628, Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

Scer\GAL4^ptc-559.1, scrib^HMS01490 has increased size | larval stage phenotype, non-suppressible by E(bx)^HMS00065, Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

Scer\GAL4^ptc-559.1, scrib^HMS01490 has increased cell death | larval stage phenotype, non-suppressible by Iswi^HMS00628, Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

Scer\GAL4^ptc-559.1, scrib^HMS01490 has increased cell death | larval stage phenotype, non-suppressible by E(bx)^HMS00065, Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

Other

Statement

Reference

Scer\GAL4^Bx-MS1096, brm^{K804R.UAS.Tag:HA}, scrib^HMS01490 has lethal phenotype

(Bunker et al., 2015)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^ptc-559.1, scrib^HMS01490 has wing disc | larval stage phenotype, non-enhanceable by Iswi^HMS00628, Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

Scer\GAL4^ptc-559.1, scrib^HMS01490 has wing disc | larval stage phenotype, non-enhanceable by E(bx)^HMS00065, Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

Suppressed by

Statement

Reference

Scer\GAL4^ptc-559.1, scrib^HMS01490 has wing disc | larval stage phenotype, suppressible by Scer\GAL4^ptc-559.1/wts^UAS.Tag:MYC

(Huang et al., 2023)

Scer\GAL4^ptc-559.1, scrib^HMS01490 has wing disc | larval stage phenotype, suppressible by Scer\GAL4^ptc-559.1/kune::α-Cat^UAS.Tag:MYC

(Huang et al., 2023)

Scer\GAL4^Bx-MS1096, scrib^HMS01490 has wing disc | third instar larval stage phenotype, suppressible by Socs36E^UASp.cCa/Scer\GAL4^Bx-MS1096

(Bunker et al., 2015)

Scer\GAL4^Bx-MS1096, scrib^HMS01490 has wing disc | third instar larval stage phenotype, suppressible by dome^ΔCYT.UAS/Scer\GAL4^Bx-MS1096

(Bunker et al., 2015)

NOT suppressed by

Statement

Reference

Scer\GAL4^ptc-559.1, scrib^HMS01490 has wing disc | larval stage phenotype, non-suppressible by Scer\GAL4^ptc-559.1/shg::α-Cat^{dCyt.UAS.Tag:MYC}

(Huang et al., 2023)

Scer\GAL4^ptc-559.1, scrib^HMS01490 has wing disc | larval stage phenotype, non-suppressible by Iswi^HMS00628, Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

Scer\GAL4^ptc-559.1, scrib^HMS01490 has wing disc | larval stage phenotype, non-suppressible by E(bx)^HMS00065, Scer\GAL4^ptc-559.1

(Sharp et al., 2021)

Scer\GAL4^{VP16.mat.αTub67C}, scrib^HMS01490 has embryonic epidermis | maternal effect phenotype, non-suppressible by cyst^HMS01750/Scer\GAL4^{VP16.mat.αTub67C}

(Silver et al., 2019)

Scer\GAL4^{VP16.mat.αTub67C}, scrib^HMS01490 has embryonic/larval cuticle | maternal effect | embryonic stage phenotype, non-suppressible by cyst^HMS01750/Scer\GAL4^{VP16.mat.αTub67C}

(Silver et al., 2019)

Suppressor of

Statement

Reference

Scer\GAL4^{VP16.mat.αTub67C}/scrib^HMS01490 is a suppressor | partially of embryonic epidermis | maternal effect | progressive phenotype of Scer\GAL4^{VP16.mat.αTub67C}, cyst^HMS01750

(Silver et al., 2019)

Scer\GAL4^{VP16.mat.αTub67C}/scrib^HMS01490 is a suppressor | partially of embryonic/larval cuticle | maternal effect | embryonic stage phenotype of Scer\GAL4^{VP16.mat.αTub67C}, cyst^HMS01750

(Silver et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Maternal co-expression of cyst^HMS01750 and scrib^HMS01490 under the control of Scer\GAL4^{VP16.mat.αTub67C} leads to embryonic cuticle defects that are similar to those induced by the expression of scrib^HMS01490 alone (i.e. epidermal cell clusters surrounded by cuticle), and milder than those induced by the expression of cyst^HMS01750 alone.

(Silver et al., 2019)

The tumor phenotype induced by the expression of scrib^HMS01490 under the control of Scer\GAL4^Bx-MS1096 is suppressed by the co-expression of Socs36E^{Scer\UAS.P\T.cCa} or dome^{ΔCYT.Scer\UAS}.

The co-expression of scrib^HMS01490 and brm^{K804R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Bx-MS1096 is synthetic lethal.

(Bunker et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

scrib^HMS01490 is rescued by scrib^Ubi.EGFP

(Huang et al., 2023)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

35748

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01490}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

scrib^HMS01490

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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