Allele Dmel\thoc5¹

General Information
Symbol	Dmel\thoc5¹	Species	D. melanogaster
Name		FlyBase ID	FBal0263654
Feature type	allele	Associated gene	Dmel\thoc5

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference An in frame deletion of 255 bp in exon 5 of thoc5. (Moon et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	male sterile (with thoc5^e00906) (Moon et al., 2011)
Phenotype Manifest In
	condensed nuclear chromosome (Moon et al., 2011) nucleolus (Moon et al., 2011) spermatid (Moon et al., 2011) spermatid (with thoc5^e00906) (Moon et al., 2011)
Detailed Description
	Statement Reference thoc5[1]/thoc5[e00906] and homozygous thoc5[1] mutant testes contain primary spermatocytes but lack post-meiotic cells. thoc5[1] mutant spermatocytes show abnormally strong condensation of three major bivalent chromosomes and the phase-dark structure of the nucleolus is severely disorganised. thoc5[1]/thoc5[e00906] trans-heterozygotes are male sterile. (Moon et al., 2011)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Expression of Mmus\Thoc5[Scer\UAS.cMa] under the control of Scer\GAL4[da.G32] partially rescues the mutant testis phenotypes. Nucleolar structure is restored to normal. Chromosome condensation is much similar to wild-type, although chromosome shape appear somewhat abnormal. Elongating spermatid flagella are observed. (Moon et al., 2011)
Complementation & Rescue Data
Rescued by	thoc5¹ is rescued by thoc5^+t7.9 (Moon et al., 2011)
Comments	thoc5[+t7.9] rescues the meiotic arrest phenotype of thoc5[1]. (Moon et al., 2011)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	garm¹ (Moon et al., 2011) thoc5¹ (Moon et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Moon et al., 2011, Development 138(17): 3835--3845 The THO complex is required for nucleolar integrity in Drosophila spermatocytes. [FBrf0214600]

Allele Dmel\thoc51

Allele Dmel\thoc5¹