|Feature type||allele||Associated gene||Hsap\APP|
|Mutagen||in vitro construct - regulatory fusion, in vitro construct - coding region fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
Expression of Hsap\APP[Aβ42.Scer\UAS.T:hh] under the control of Scer\GAL4[GMR.PF] causes progressive eye degeneration correlated with age and expression levels. The eye distortion phenotype is enhanced by zinc or copper ion food supplements. The eye degeneration is ameliorated by zinc/copper and copper chelators. In control flies not expressing Hsap\APP[Aβ42.Scer\UAS.T:hh], normal eye structure is not affected by copper or zinc ion treatment. The eye degeneration phenotype caused by expression of Hsap\APP[Aβ42.Scer\UAS.T:hh] under the control of Scer\GAL4[GMR.PF] is strongly enhanced by hydrogen peroxide at a dosage that does not affect wild-type flies. Expression of Hsap\APP[Aβ42.Scer\UAS.T:hh] under the control of Scer\GAL4[Act.PU] reduces viability, evident as a lower eclosion rate. Viability is further reduced by dietary zinc ion supplement, but not by copper ion supplement or copper depletion. The decline in survival is counteracted by supplementing DP-109 (a Zn/Cu metal chelator) in the food, but not by supplementing another Cu-only specific chelator, BCS. When the expression of Hsap\APP[Aβ42.Scer\UAS.T:hh] is directed to the nervous system by using a neuron specific driver (Scer\GAL4[elav.PLu]), the flies exhibit defects in locomotion which is more severe upon dietary zinc ion supplementation, as measured by a standard climbing assay. Zinc ion chelators ameliorate this phenotype.
|Phenotype Manifest In|
Hsap\APPAβ42.Scer\UAS.T:SS-hh, Scer\GAL4GMR.PF has eye phenotype, suppressible by MTF-1Scer\UAS.cHa, Scer\GAL4GMR.PF
Co-expression of MTF-1[Scer\UAS.cHa] with Hsap\APP[Aβ42.Scer\UAS.T:hh] under the control of Scer\GAL4[GMR.PF] ameliorates the eye phenotype caused by Hsap\APP[Aβ42.Scer\UAS.T:hh] expression alone. Co-expression of MtnA[Scer\UAS.cHa] with Hsap\APP[Aβ42.Scer\UAS.T:hh] under the control of Scer\GAL4[GMR.PF] ameliorates the eye phenotype caused by Hsap\APP[Aβ42.Scer\UAS.T:hh] expression alone. MTF-1[unspecified] enhances the eye phenotype caused by expression of Hsap\APP[Aβ42.Scer\UAS.T:hh] under the control of Scer\GAL4[GMR.PF].
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 1 )|