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General Information
Symbol
Dmel\Vha100-1R755A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0264500
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of a mutated form of Vha100-1 that contains the amino acid replacement R755A.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Scer\GAL4drm.7.1-mediated expression of Vha100-1R755A.Scer\UAS results in tracheal stalk cells aberrantly forming two or more connections to a neighbouring terminal cell and long, branched autocellular, seamed tubes extending well beyond the terminal cell nucleus.
The electroretinogram has an on transient, but shows a decrease in depolarisation compared to wild type in photoreceptors in which Vha100-1R755A.Scer\UAS is expressed under the control of Scer\GAL4unspecified. Animals expressing Vha100-1R755A.Scer\UAS under the control of Scer\GAL4unspecified in a Vha100-14 background show loss of photoreceptors and have a reduced eye phenotype.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
The on transient of the electroretinogram is significantly rescued in Vha100-14 mutant photoreceptors in which Vha100-1R755A.Scer\UAS is expressed under the control of Scer\GAL4unspecified, although this is accompanied by a pronounced decrease in electroretinogram depolarisation. The acidification defects seen in Vha100-14 mutant photoreceptors after neuronal differentiation are not rescued by expression of Vha100-1R755A.Scer\UAS in the photoreceptors under the control of Scer\GAL4unspecified.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Vha100-1R755A.Scer\UAS
Vha100-1R755A.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)