Allele Dmel\mop^sfv3

General Information
Symbol	Dmel\mop^sfv3	Species	D. melanogaster
Name		FlyBase ID	FBal0264533
Feature type	allele	Associated gene	Dmel\mop

Allele class	hypomorphic allele - molecular evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - molecular evidence (Gilbert et al., 2011)
Mutagen	ethyl methanesulfonate (Gilbert et al., 2011)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Contains a nonsense mutation in the seventh exon of mop, resulting in truncation within the C-terminal region, just prior to the PTPase catalytic region. (Gilbert et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Gilbert et al., 2011) size defective \| adult stage \| somatic clone (Gilbert et al., 2011)
Phenotype Manifest In
	eye \| somatic clone (Gilbert et al., 2011)
Detailed Description
	Statement Reference Mosaic mop[sfv3] adult eyes (generated using the eyFLP method) are small and rough and contain little to no mutant tissue. (Gilbert et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Df(3L)H99, mop^sfv3 has size defective \| adult stage \| somatic clone - Minute background phenotype, suppressible by Scer\GAL4^Act.PU/ex^{CT.Scer\UAS.P\T.T:Avic\GFP-EGFP} (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has size defective \| adult stage \| somatic clone - Minute background phenotype, suppressible by Scer\GAL4^Act.PU/ex^Scer\UAS.cBa (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has size defective \| adult stage \| somatic clone - Minute background phenotype, suppressible by Scer\GAL4^Act.PU/ex^{Scer\UAS.P\T.T:Avic\GFP-EGFP} (Gilbert et al., 2011)
NOT suppressed by
Statement Reference Df(3L)H99, mop^sfv3 has size defective \| adult stage \| somatic clone - Minute background phenotype, non-suppressible by Scer\GAL4^Act.PU/app^{dsRNA.Scer\UAS.cMa} (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has size defective \| adult stage \| somatic clone - Minute background phenotype, non-suppressible by Scer\GAL4^Act.PU/ex^{linker.Scer\UAS.P\T.T:Avic\GFP-EGFP} (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has size defective \| adult stage \| somatic clone - Minute background phenotype, non-suppressible by Scer\GAL4^Act.PU/wts^{Scer\UAS.T:Hsap\MYC} (Gilbert et al., 2011)
Enhancer of
Statement Reference mop^sfv3, Scer\GAL4^GMR.PFa is an enhancer of size defective \| adult stage phenotype of Hsap\YAP1^Scer\UAS.cHa, Scer\GAL4^GMR.PFa (Gilbert et al., 2011)
Other
Statement Reference Df(3L)H99, mop^sfv3 has increased cell number \| somatic clone \| larval stage phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has increased cell number \| somatic clone \| pupal stage phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has lethal \| pharate adult stage \| somatic clone - Minute background phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has mitotic cell cycle defective \| somatic clone phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has size defective \| adult stage \| somatic clone - Minute background phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has size defective \| somatic clone \| adult stage phenotype (Gilbert et al., 2011)
Phenotype Manifest In
Suppressed by
Statement Reference Df(3L)H99, mop^sfv3 has head \| somatic clone - Minute background phenotype, suppressible by Scer\GAL4^Act.PU/ex^{CT.Scer\UAS.P\T.T:Avic\GFP-EGFP} (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has head \| somatic clone - Minute background phenotype, suppressible by Scer\GAL4^Act.PU/ex^Scer\UAS.cBa (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has head \| somatic clone - Minute background phenotype, suppressible by Scer\GAL4^Act.PU/ex^{Scer\UAS.P\T.T:Avic\GFP-EGFP} (Gilbert et al., 2011)
NOT suppressed by
Statement Reference Df(3L)H99, mop^sfv3 has head \| somatic clone - Minute background phenotype, non-suppressible by Scer\GAL4^Act.PU/app^{dsRNA.Scer\UAS.cMa} (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has head \| somatic clone - Minute background phenotype, non-suppressible by Scer\GAL4^Act.PU/ex^{linker.Scer\UAS.P\T.T:Avic\GFP-EGFP} (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has head \| somatic clone - Minute background phenotype, non-suppressible by Scer\GAL4^Act.PU/wts^{Scer\UAS.T:Hsap\MYC} (Gilbert et al., 2011)
Enhancer of
Statement Reference mop^sfv3 is an enhancer of eye phenotype of Hsap\YAP1^Scer\UAS.cHa, Scer\GAL4^GMR.PFa (Gilbert et al., 2011)
Other
Statement Reference Df(3L)H99, mop^sfv3 has adult cuticle \| somatic clone - Minute background phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has eye \| somatic clone - Minute background phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has eye \| somatic clone phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has haltere \| somatic clone - Minute background phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has head \| somatic clone - Minute background phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has inter-ommatidial cell \| supernumerary \| somatic clone \| pupal stage phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has thorax \| somatic clone - Minute background phenotype (Gilbert et al., 2011) Df(3L)H99, mop^sfv3 has wing disc \| somatic clone \| third instar larval stage phenotype (Gilbert et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference Mosaic mop[sfv3] Df(3L)H99 adult eyes (generated using the eyFLP method) exhibit a clonal growth advantage compared to Df(3L)H99 controls. Flies with heads composed entirely of mop[sfv3] Df(3L)H99 clone cells (generated in a minute background) die at the pharate adult stage with extra folds of head cuticle relative to controls. The eyes are constricted at their margins, protrude from the head and contain enlarged facets. Generation of mop[sfv3] Df(3L)H99 mutant clones throughout the body (generated in a minute background) results in outgrowths in the thorax and increased haltere size compared to Df(3L)H99 mutants alone. Excess interommatidial cells are seen in mop[sfv3] Df(3L)H99 pupal clones in comparison with Df(3L)H99 controls. Pupal clones also exhibit patterning defects. Ectopic S phase cells are seen in mop[sfv3] Df(3L)H99 mutant eye clones posterior to the second mitotic wave. These cells are post-mitotic in both wild type and Df(3L)H99 controls. mop[sfv3] Df(3L)H99 clones in the third instar larval wing disc epithelium are consistently larger, contain more cells than twin spots in controls and have regular boundaries. DNA content and size are also similar to Df(3L)H99 controls. Expression of wts[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[Act.PU] does not suppress the head overgrowth seen in mop[sfv3] Df(3L)H99 mutant clones (generated in a minute background). Expression of ex[Scer\UAS.cBa] under the control of Scer\GAL4[Act.PU] suppresses the head overgrowth seen in mop[sfv3] Df(3L)H99 mutant clones (generated in a minute background). Expression of ex[Scer\UAS.P\T.T:Avic\GFP-EGFP] under the control of Scer\GAL4[Act.PU] suppresses the head overgrowth seen in mop[sfv3] Df(3L)H99 mutant clones (generated in a minute background). Expression of ex[CT.Scer\UAS.P\T.T:Avic\GFP-EGFP] under the control of Scer\GAL4[Act.PU] suppresses the head overgrowth seen in mop[sfv3] Df(3L)H99 mutant clones (generated in a minute background). Expression of ex[linker.Scer\UAS.P\T.T:Avic\GFP-EGFP] under the control of Scer\GAL4[Act.PU] fails to suppress the head overgrowth seen in mop[sfv3] Df(3L)H99 mutant clones (generated in a minute background). Expression of app[dsRNA.Scer\UAS.cMa] under the control of Scer\GAL4[Act.PU] fails to suppress the head overgrowth seen in mop[sfv3] Df(3L)H99 mutant clones (generated in a minute background). (Gilbert et al., 2011)
Xenogenetic Interactions
Statement Reference :One copy of mop[sfv3] enhances the eye overgrowth phenotype seen when Hsap\YAP1[Scer\UAS.cHa] is expressed under the control of Scer\GAL4[GMR.PFa]. (Gilbert et al., 2011)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	F2.6.3 (Gilbert et al., 2011) mop^sfv3 (Gilbert et al., 2011) sfv³ (Gilbert et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Gilbert et al., 2011, Dev. Cell 20(5): 700--712 A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie. [FBrf0213686]

Allele Dmel\mopsfv3

Allele Dmel\mop^sfv3