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General Information
Symbol
Dmel\Sec6Ex15
Species
D. melanogaster
Name
FlyBase ID
FBal0264707
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Deletion of part of sec6 resulting from imprecise excsion of P{EP}Eip55EEP2021. The deletion location was estimated from the report that the Eip55EEx15 deletion extends from amino acid 397 of sec6 to the 21st base pair of the 5? untranslated region of Eip55E. The deletion was mapped from the first base of sec6 codon 397 to the insertion site of P{EP}Eip55EEP2021 in the 5' UTR of Eip55E.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion has resulted in a deletion that extends from the codon encoding amino acid residue 397 of sec6 through the end of the transcription unit and continues to the 21st base pair of the 5' untranslated region of the neighbouring Eip55E gene.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Sec6Ex15/Sec6Ex15 class IV da neurons in larval somatic clones manifest defects in dendritic growth (thinning of terminal dendrites, reduced total dendrite length and number of terminal branches, decreased number of dendritic intersections, varicosities).

Homozygous, sec6Ex15/Df(2R)PC4 and sec6Ex15/Df(2R)Ex212 larvae die from growth arrest at 96 hours after egg laying (AEL). The larvae are much smaller than normal, never being larger than wild-type larvae at 24 hours AEL.

Females containing homozygous germline clones do not lay eggs. Egg chambers form and exit the germarium in these females, but after stage 3, cell membranes are frequently absent between the germ line cells and ring canals are clumped together in the middle of a large, multinucleate cell. When individual cells can be distinguished in the mutant egg chamber, the oocyte is often mispositioned anteriorly.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Sec6Ex15/RopG27 transheterozygous third instar larvae show decreased number of terminal dendritic branches in the class IV dendritic arborizing neurons compared to either Sec6Ex15/+ or RopG27/+ single heterozygotes.

The fraction of oocytes showing endocytic activity is reduced compared to wild type in EndoB54/Sec6Ex15 double heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)