FB2025_01 , released February 20, 2025
Allele: Dmel\Ptp10Dchi
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General Information
Symbol
Dmel\Ptp10Dchi
Species
D. melanogaster
Name
FlyBase ID
FBal0264718
Feature type
allele
Associated gene
Dmel\Ptp10D
Associated Insertion(s)
P{}Ptp10Dchi
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Qian et al., 2007)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{}Ptp10Dchi
    Cytology
    Description

    Insertion in the first intron, 345bp downstream of the splice donor site of exon 1 and 943bp upstream of the start codon in exon 2.

    (Qian et al., 2007)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous and Ptp10Dchi/Ptp10DEP1172 flies show significantly lower 1 day memory after spaced training compared to control flies.

        Homozygous flies show normal 1 day memory after massed training and show normal memory both immediately and 3 hours after one training session.

        (Qian et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Ptp10Dchi is rescued by Ptp10Dhs.PQ

        (Qian et al., 2007)

        Ptp10Dchi is rescued by Scer\GAL4ey-OK107/Ptp10DUAS.cQa

        (Qian et al., 2007)

        Ptp10Dchi is rescued by Scer\GAL4c309/Ptp10DUAS.cQa

        (Qian et al., 2007)
        Not rescued by

        Ptp10Dchi is not rescued by Scer\GAL4Alp4-c232/Ptp10DUAS.cQa

        (Qian et al., 2007)
        Comments

        Expression of Ptp10Dhs.PQ using heat shock rescues the memory defects (reduced 1 day memory after spaced training) of Ptp10Dchi flies when the animals are trained 3 hours after the heat shock treatment.

        Expression of Ptp10DScer\UAS.cQa under the control of either Scer\GAL4c309 or Scer\GAL4ey-OK107 rescues the memory defects (reduced 1 day memory after spaced training) of Ptp10Dchi flies.

        Expression of Ptp10DScer\UAS.cQa under the control of Scer\GAL4Aph-4-c232 fails to rescue the memory defects (reduced 1 day memory after spaced training) of Ptp10Dchi flies.

        (Qian et al., 2007)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Ptp10Dchi
        chi
        (Qian et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)