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General Information
Symbol
Dmel\TgA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0264822
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dTG-A
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of 2.3kb of Tg isoform A coding sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of TgA.Scer\UAS driven by Scer\GAL4GMR.PU results in a mild rough eye phenotype (disrupted ommatidial array organisation and bristle loss).

Expression of TgA.Scer\UAS in the region posterior to the morphogenic furrow in the eye imaginal disc, under the control of Scer\GAL4GMR.PS or in the posterior compartment of the wing imaginal disc, under the control of Scer\GAL4en.PU, causes a rough eye phenotype in the compound eyes and an extra wing crossvein phenotype in the wings.

Expression of TgA.Scer\UAS mainly in the border between the anterior and the posterior compartment of the wing imaginal disc, under the control of Scer\GAL4dpp.blk1, causes an extra wing crossvein phenotype in and around the border.

Expression of TgA.Scer\UAS mainly in the border between the anterior and the posterior compartment of the wing imaginal disc, under the control of Scer\GAL4ptc-559.1, results in an extra wing crossvein phenotype.

Expression of TgA.Scer\UAS mainly in the wing pouch of the wing imaginal disc, under the control of Scer\GAL4c179, results in an extra wing crossvein phenotype.

Expression of TgA.Scer\UAS under the control of Scer\GAL4ey.PU, Scer\GAL4Dll.PU, Scer\GAL4Bx-MS1096, Scer\GAL4pnr-MD237, Scer\GAL4Cg.PA or Scer\GAL469B does not generate any morphological change.

Expression of TgA.Scer\UAS with Scer\GAL4GMR.PS causes a rough eye phenotype in adult eyes. The ommatidia lack their regular hexagonal shape and some missing bristles are apparent. This phenotype is repressed at low temperatures (e.g. 19[o]C).

Expression of TgA.Scer\UAS under the control of Scer\GAL4ey.PH, Scer\GAL4Dll-md23, Scer\GAL4Bx-MS1096, Scer\GAL4sd.PU, Scer\GAL4pnr-MD237, Scer\GAL4Cg.PA or Scer\GAL469B does not cause any apparent morphological changes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

Scer\GAL4GMR.PS, TgA.UAS has eye phenotype, suppressible by bsk1/bsk[+]

Scer\GAL4GMR.PS, TgA.UAS has ommatidium phenotype, suppressible by bsk1/bsk[+]

Scer\GAL4GMR.PS, TgA.UAS has ommatidium phenotype, suppressible by hep[+]/hepr75

Scer\GAL4GMR.PS, TgA.UAS has eye phenotype, suppressible by bsk2/bsk[+]

Scer\GAL4GMR.PS, TgA.UAS has ommatidium phenotype, suppressible by bsk2/bsk[+]

Scer\GAL4GMR.PS, TgA.UAS has eye phenotype, suppressible by hep[+]/hep1

Scer\GAL4GMR.PS, TgA.UAS has ommatidium phenotype, suppressible by hep[+]/hep1

Scer\GAL4GMR.PS, TgA.UAS has eye phenotype, suppressible by hep[+]/hepr75

Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of TgA.Scer\UAS and Pink1Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4GMR.PU results in enhanced rough eye phenotypes compared to expression of either construct alone. Co-expression of Pink1NIG.4523R suppresses the mild rough eye phenotype seen in flies with TgA.Scer\UAS driven by Scer\GAL4GMR.PU.

A bsk1/+, bsk2/+, hepr75/+, or a hep1/+ background suppressed the rough eye phenotype found upon expression of TgA.Scer\UAS under the control of Scer\GAL4GMR.PS.

Xenogenetic Interactions
Statement
Reference

Co-expression of BacA\p35Scer\UAS.cHa, suppresses the rough eye phenotype induced by the overexpression of TgA.Scer\UAS in the eye imaginal disc under the control of Scer\GAL4GMR.PS.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
TgA.Scer\UAS
TgA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)