Allele Dmel\SNF1A^{dsRNA.Scer\UAS}

General Information
Symbol	Dmel\SNF1A^{dsRNA.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0264828
Feature type	allele	Associated gene	Dmel\SNF1A

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - RNAi
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Johnson et al., 2010) in vitro construct - RNAi (Johnson et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of SNF1A coding sequences arranged in an inverted repeat to generate dsRNA. (Johnson et al., 2010)
Carried in construct	P{UAS-SNF1A.dsRNA} (Johnson et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage, with Scer\GAL4^αTub84B.PL (Johnson et al., 2010) neuroanatomy defective, with Scer\GAL4^109(2)80 (Johnson et al., 2010) short lived \| nutrition conditional, with Scer\GAL4^hs.PB (Johnson et al., 2010) starvation stress response defective, with Scer\GAL4^hs.PB (Johnson et al., 2010)
Phenotype Manifest In
	class IV dendritic arborizing neuron, with Scer\GAL4^109(2)80 (Johnson et al., 2010)
Detailed Description
	Statement Reference Expression of SNF1A[dsRNA.Scer\UAS] under the control of Scer\GAL4[109(2)80] results in aberrant morphology in class IV multi-dendritic neurons. Heat-shock induced expression of SNF1A[dsRNA.Scer\UAS] (under the control of Scer\GAL4[hs.PB]) in adult stages produces a significant reduction in starvation survival. Starvation sensitivity is indistinguishable in these animals from controls. These animals also exhibit a significant reduction in lifespan under nutrient-rich conditions. (Johnson et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference SNF1A^{dsRNA.Scer\UAS}, Scer\GAL4^αTub84B.PL has lethal \| larval stage phenotype, suppressible \| partially by Tor^TED.Scer\UAS, Scer\GAL4^αTub84B.PL (Johnson et al., 2010)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Expression of dominant-negative Tor[TED.Scer\UAS] partially rescues the lethality cause by global expression (Scer\GAL4[αTub84B.PL]) of SNF1A[dsRNA.Scer\UAS]. (Johnson et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	SNF1A^{dsRNA.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Johnson et al., 2010, PLoS ONE 5(9): e12799 Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila. [FBrf0211905]

Allele Dmel\SNF1AdsRNA.Scer\UAS

Allele Dmel\SNF1A^{dsRNA.Scer\UAS}