Allele Dmel\Upf1^13D

General Information
Symbol	Dmel\Upf1^13D	Species	D. melanogaster
Name		FlyBase ID	FBal0264863
Feature type	allele	Associated gene	Dmel\Upf1

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Metzstein and Krasnow, 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: C186Y. (Metzstein and Krasnow, 2006)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| male limited \| second instar larval stage (Metzstein and Krasnow, 2006)
Phenotype Manifest In
	adult tracheal system \| somatic clone (Metzstein and Krasnow, 2006) dorsal appendage (Avery et al., 2011) eye \| somatic clone (Metzstein and Krasnow, 2006) follicle cell \| somatic clone (Avery et al., 2011)
Detailed Description
	Statement Reference 83.4% of eggs derived from homozygous female germlines show a fused dorsal appendage phenotype. Homozygous follicle cell clones are smaller than wild-type clones both in early, proliferating egg chambers and in late, endocycling egg chambers. (Avery et al., 2011) While homozygous mutant Upf1[13D] clones are readily obtained from the larval tracheal system, clones are not recovered in the adult system. Large clones are also not recovered from the adult epidermis or eyes, Although small peripheral eye clones are occasionally observed. (Metzstein and Krasnow, 2006)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Upf1^26A (Metzstein and Krasnow, 2006)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	upf1^13D (Avery et al., 2011) Upf1^13D (Metzstein and Krasnow, 2006)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Avery et al., 2011, RNA 17(4): 624--638 Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. [FBrf0213282] Metzstein and Krasnow, 2006, PLoS Genet. 2(12): e180 Functions of the nonsense-mediated mRNA decay pathway in Drosophila development. [FBrf0194265]

Allele Dmel\Upf113D

Allele Dmel\Upf1^13D