Allele Dmel\Nc^{S130A.Scer\UAS}

General Information
Symbol	Dmel\Nc^{S130A.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0264882
Feature type	allele	Associated gene	Dmel\Nc

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - amino acid replacement
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Yang et al., 2010) in vitro construct - regulatory fusion (Yang et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: S130A. (Yang et al., 2010) Scer\UAS regulatory sequences drive expression of Nc coding sequences containing an amino acid substitution that results in a non-phosphorylatable form of Nc. (Yang et al., 2010)
Carried in construct	P{UAS-Nc.S130A} (Yang et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	increased cell death, with Scer\GAL4^GMR.PF (Yang et al., 2010)
Phenotype Manifest In
	eye, with Scer\GAL4^GMR.PF (Yang et al., 2010) wing, with Scer\GAL4^elav-C155 (Yang et al., 2010)
Detailed Description
	Statement Reference Scer\GAL4[GMR.PF]-driven overexpression of Nc[S130A.Scer\UAS] results in a rough eye phenotype. Expression of Nc[S130A.Scer\UAS] pan-neuronally under the control of Scer\GAL4[elav-C155] results in severe wing expansion defects. (Yang et al., 2010)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement Reference Nc^{S130A.Scer\UAS}, Scer\GAL4^elav-C155 has wing phenotype, non-enhanceable by Men^{dsRNA.Scer\UAS}, Scer\GAL4^elav-C155 (Yang et al., 2010)
NOT suppressed by
Statement Reference Nc^{S130A.Scer\UAS}, Scer\GAL4^elav-C155 has wing phenotype, non-suppressible by Men^{dsRNA.Scer\UAS}, Scer\GAL4^elav-C155 (Yang et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Down-regulation of Men through expression of Men[dsRNA.Scer\UAS] under the control of Scer\GAL4[elav-C155] has no effect on the severe wing expansion defects seen upon expression of Nc[S130A.Scer\UAS]. (Yang et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Nc^{S130A.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Yang et al., 2010, EMBO J. 29(18): 3196--3207 Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. [FBrf0211843]

Allele Dmel\NcS130A.Scer\UAS

Allele Dmel\Nc^{S130A.Scer\UAS}