FB2025_01 , released February 20, 2025
Allele: Dmel\Hipkw.D1
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General Information
Symbol
Dmel\Hipkw.D1
Species
D. melanogaster
Name
FlyBase ID
FBal0264886
Feature type
allele
Associated gene
Dmel\Hipk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Link et al., 2007)
Progenitor genotype
Hipkd10792
(Link et al., 2007)
Hipkf03158
(Link et al., 2007)
Cytology
Description

FLP-mediated transposition of PBac{WH}hipkf03158 and P{XP}hipkd10792 generates a deletion that removes ~92% of the hipk coding region by replacing residues 1-1243 with the w+ marker gene.

(Link et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:548,527..580,867 [+]
Comment:

FLP-mediated transposition of PBac{WH}Hipkf03158 and P{XP}Hipkd10792 generates a deletion that removes ~92% of the Hipk coding region by replacing residues 1-1243 with the w+ marker gene.

(Link et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wings mosaic for hipkw.D1 are normal at eclosion, but upon aging show severe blemishing and persisting cell phenotypes.

      hipkw.D1 mutants are lethal before the 3rd instar stage. Approximately 70% of hipkw.D1 homozygotes hatch to 1st instar larvae.

      Zygotic hipkw.D1 animals possess cell numbers equivalent to wild-type, but maternal hipkw.D1 embryos have supernumerary cells comparable to levels seem in apoptosis-deficient embryos (i.e. Df(3L)H99 embryos). hipkw.D1 mutants show extra exex-positive cells and altered CNS patterning. hipkw.D1 mutant pupal eyes exhibit more interommatidial cells, indicative of a defect in cell death. Distorted patterning of ommatidia and abnormal numbers of primary pigment cells are also seen in a subset of animals.

      (Link et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hipkw.D1
      hipkD1
      (Link et al., 2007)
      hipkw.D1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)