Allele Dmel\Nak^{KD.Scer\UAS.T:Hsap\MYC}

General Information
Symbol	Dmel\Nak^{KD.Scer\UAS.T:Hsap\MYC}	Species	D. melanogaster
Name		FlyBase ID	FBal0264902
Feature type	allele	Associated gene	Dmel\Nak

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion, in vitro construct - amino acid replacement
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Yang et al., 2011) in vitro construct - coding region fusion (Yang et al., 2011) in vitro construct - regulatory fusion (Yang et al., 2011)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of a mutated form of Nak, which contains the amino acid replacements K79R and R304K (kinase dead mutant). The protein is also tagged with T:Hsap\MYC. (Yang et al., 2011)
Carried in construct	P{UAS-Nak.KD} (Yang et al., 2011)
Tagged with	T:Hsap\MYC (Yang et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| larval stage, with Scer\GAL4^109(2)80 (Yang et al., 2011)
Phenotype Manifest In
	dendrite \| larval stage, with Scer\GAL4^109(2)80 (Yang et al., 2011) dendritic arborizing neuron \| larval stage, with Scer\GAL4^109(2)80 (Yang et al., 2011)
Detailed Description
	Statement Reference The number of dendritic endpoints of dorsal dendritic arborisation neurons is reduced compared to controls in larvae expressing Nak[KD.Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[109(2)80]. (Yang et al., 2011)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to rescue	Scer\GAL4^109(2)80/Nak^{KD.Scer\UAS.T:Hsap\MYC} fails to rescue Nak^{dsRNA.Scer\UAS} (Yang et al., 2011) Scer\GAL4^elav-C155/Nak^{KD.Scer\UAS.T:Hsap\MYC} fails to rescue Nak^{dsRNA.Scer\UAS} (Yang et al., 2011)
Comments	Co-expression of Nak[KD.Scer\UAS.T:Hsap\MYC] fails to rescue the dendritic defects seen in the dorsal dendritic arborisation neurons of larvae expressing Nak[dsRNA.Scer\UAS] under the control of Scer\GAL4[109(2)80]. Co-expression of Nak[KD.Scer\UAS.T:Hsap\MYC] fails to rescue the dendritic defects seen in the dorsal dendritic arborisation neurons of larvae expressing Nak[dsRNA.Scer\UAS] under the control of Scer\GAL4[elav-C155]. (Yang et al., 2011)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Nak^{KD.Scer\UAS.T:Hsap\MYC}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Yang et al., 2011, Neuron 72(2): 285--299 Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. [FBrf0216477]

Allele Dmel\NakKD.Scer\UAS.T:Hsap\MYC

Allele Dmel\Nak^{KD.Scer\UAS.T:Hsap\MYC}