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General Information
Symbol
Dmel\Uba1H33
Species
D. melanogaster
Name
FlyBase ID
FBal0265021
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C9689750T

Amino acid change:

P884L | Uba1-PA; P701L | Uba1-PC

Reported amino acid change:

P884L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: P884L.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones cannot be recovered in the adult eye at 29[o]C (they undergo apoptosis). However, despite the absence of mutant clones, these eyes are often larger than normal and contain folds, indicating overgrowth. Third larval instar discs are overgrown in mosaic animals raised at 29[o]C. Although homozygous clones are present in the overgrown discs, they are relatively small compared with controls and so do not contribute to the overgrowth.

At 25[o]C, homozygous clones in the eye survive well and are recovered in adults.

Homozygous clones in the eye disc contain extra interommatidial cells compared to controls at 42 hours after puparium formation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The small eye phenotype caused by WGMR.PG is moderately strongly suppressed by inducing homozygous Uba1H33 clones in the eye. The rescued eye tissue is homozygous for Uba1H33, indicating that the suppression is cell autonomous.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)