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General Information
Symbol
Dmel\hidGMR.PG
Species
D. melanogaster
Name
glass multimer reporter construct of Grether
FlyBase ID
FBal0265023
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GMR-hid, GMRhid, pGMR-hid, GMR>hid, P[GMR-hid], PGMR-hid, GMR-hid10
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Expression of 3.9kb EcoRI fragment containing the hid cDNA is driven by GMR regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

hidGMR.PG induces a small eye.

Expression of hidGMR.PG induces a widespread cell death in the developing visual system resulting in very small adult eyes.

Expression of hidGMR.PG results in small and rough eye phenotype in adult flies.

hidGMR.PG flies have an eye ablation phenotype.

Flies expressing hidGMR.PG have a reduced eye, due to increased cell death.

hidGMR.PG mutants exhibit normal light-dependent temperature preference. Similarly to wild-type, they prefer higher temperature in the light than in the dark.

As in wild type, hidGMR.PG mutant males exhibit inhibition of the female contact-induced male-male aggression seen in wild type males that have previously been exposed to females.

WGMR.PG animals display an eye-ablation phenotype as a result of massive apoptosis.

hidGMR.PG induces apoptosis in imaginal eye discs of third instar larvae.

Early third instar larvae carrying WGMR.PG show a normal avoidance response to a spot of intense light.

WGMR.PG generates a small eye phenotype due to eye ablation.

WGMR.PG flies have a small eye.

WGMR.PG third larval instar eye discs show increased apoptosis posterior to the second mitotic wave as well as in the posterior region of the eye disc within an additional region of cell division called the zone of compensatory proliferation.

Flies expressing hidGMR.PG show eye defects.

Flies carrying WGMR.PG show ectopic cell death in the eye.

WGMR.PG eyes are ablated.

WGMR.PG adult flies have very small eyes.

Eyes are highly ablated and abnormally shaped.

Flies expressing WGMR.PG have smaller eyes than normal.

Expression of WGMR.PG under the control of Scer\GAL4GMR.PF causes a dramatic reduction in adult eye size.

Flies carrying WGMR.PG have a small eye phenotype, due to increased apoptotic cell death in the developing eye disc.

WGMR.PG eye clones result in a small eye phenotype.

Expression of WGMR.PG results in ablation of the eye.

hidGMR.PG mutants exhibit a small, less-pigmented eye, due to apoptosis in the developing eye.

Flies expressing WGMR.PG have a small rough eye.

Flies carrying WGMR.PG show almost complete ablation of the eye.

WGMR.PG flies show a strong eye ablation phenotype.

WGMR.PG eye imaginal discs exhibit increased caspase-3 staining, indicating apoptosis, overlapping with the second mitotic wave.

WGMR.PG eye imaginal discs contain an additional zone of proliferating cells posterior to the second mitotic wave, termed the 'zone of compensatory proliferation' (ZCP). A zone of dying cells is present immediately behind this ZCP, which presumably eliminates the newly formed cells.

Flies expressing WGMR.PG show a small eye phenotype.

WGMR.PG causes a strong eye-ablation phenotype as a result of the induction of apoptosis.

Adults expressing WGMR.PG show a dramatic reduction in eye size compared to wild type.

Expression of WGMR.PG induces extensive apoptosis posterior to the morphogenetic furrow in third larval instar eye discs.

Flies that express WGMR.PG have small eyes.

Expression of the WGMR.PG transgene in postmitotic cells of the eye disc leads to small, rough eyes.

WGMR.PG flies show an eye ablation phenotype.

WGMR.PG larvae are blind.

Ablation of the larval eye by expression of WGMR.PG in all photoreceptors causes a significant reduction in the 5-HT arborization.

Expression of WGMR.PG in the eye reduces the overall size and pigmentation of the eye.

Mosaic animals in which the eyes are expressing WGMR.PG have an eye ablation phenotype.

Flies carrying WGMR.PG have rough and reduced eyes.

At high-light intensity, WGMR.PG flies are able to resynchronize to a shift in the light-dark schedule of 8 hours. However, at 1000-fold lower light intensity, WGMR.PG mutants take longer to synchronize to new schedules than wild-type flies. These mutants are unable to entrain to red light-dark schedules, to which wild-type flies can entrain.

Exposing WGMR.PG flies to constant light results in arrhythmicity, as with wild-type flies.

Flies expressing WGMR.PG have small, rough eyes.

Flies carrying WGMR.PG have a smaller eye than normal (about two-thirds the size of wild type), which is rough and glassy in the posterior half.

Mutant animals have small rough eyes.

Expression of WGMR.PG results in widespread ectopic apoptosis in the developing eye, resulting in mis-patterning of the ommatidial rows and a reduction in size of the adult eye field.

WGMR.PG results in a dosage dependent eye degeneration phenotype.

Third instar larvae expressing WGMR.PG completely lack the Bolwig's nerve and the dendritic tree of the lateral neurons is extremely reduced (being undetectable in 72% cases). The developing adult photoreceptors are present in these larvae, but degenerate during the pupal stage.

Flies expressing WGMR.PG show an eye ablation phenotype.

Mutants have small eyes.

Flies expressing WGMR.PG have an ablated eye phenotype.

Flies expressing WGMR.PG have a severely ablated eye.

Mutant larvae show significantly lower locomotion than control larvae and do not respond to light (as measured by a "checker assay"). Larval photoreceptors are either absent or severely damaged.

Eye is small and roughened.

Mutants have eyes that are severely reduced in size. The addition of Df(3L)AC1 to WGMR.PG flies shows a significant suppression of the eye phenotype seen in these eyes.

Flies carrying WGMR.PG have an ablated eye phenotype.

WGMR.PG flies have a mild but easily detectable eye phenotype.

Flies carrying rprGMR.PW have a small eye phenotype and show increased numbers of dying cells posterior to the morphogenetic furrow.

Wild-type larvae reduce their path lengths when exposed to light. This response is reduced in larvae carrying WGMR.PG. Wild-type larvae show increased head swinging when exposed to light. This response is abolished in larvae carrying WGMR.PG. Wild-type larvae show a greater change in direction when lights are turned on or off (light (L) to dark (D), or D to L transition) than in the absence of a light transition (D to D). The amplitude of change of direction is greater for the D to L than for the L to D transition. This difference in the amplitude of change of direction between the D to L and L to D transitions is abolished in larvae carrying WGMR.PG, although change of direction in the absence of a light transition (D to D) is still significantly lower than for either the D to L and L to D transition.

Two copies of WGMR.PG in an otherwise wild-type background result in a severely roughened, small eye.

Adult flies carrying one copy of WGMR.PG lack photoreceptor cells.

Eyes are severely reduced in size and devoid of most normal ommatidial morphology. The severity of the effect is dosage sensitive. Phenotypes of WGMR.PG, WAla3.GMR and WAla5.GMR are comparable. Phenotype is slightly suppressed by hemizygosity at the endogenous W locus.

Cell-killing in the eye induced by WGMR.PG is not noticeably affected by Df(1)su(s)R194.

Eye ablation due to apoptosis.

Adult eye is dramatically reduced, almost ablated. In larval eye discs, increased numbers of cells are observed posterior to the morphogenetic furrow.

Individuals carrying one copy of P{GMR-hid} display a dramatic eye ablation phenotype. In place of the compound eye is undifferentiated cuticle and a dense band of bristles (mechanosensory bristles normally found at the corner of each ommatidium). The eye phenotype can be completely suppressed by coexpression of BacA\p35.

Eyes are small.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

hidGMR.PG/WGMR.PG has visible phenotype, enhanceable by CG8830[+]/DUBAIKG07439

hidGMR.PG/WGMR.PG has visible phenotype, enhanceable by Rab11mo

hidGMR.PG/WGMR.PG has visible phenotype, enhanceable by PSR[+]/PSRFM1

hidGMR.PG/WGMR.PG has visible phenotype, enhanceable by Dunspecified

NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

hidGMR.PG has visible phenotype, suppressible by Drice17/Drice17

hidGMR.PG has visible phenotype, suppressible by DriceΔ1/Drice17

hidGMR.PG has visible phenotype, suppressible by DriceL1/Drice17

hidGMR.PG has visible phenotype, suppressible by DriceL2/Drice17

hidGMR.PG has visible phenotype, suppressible | partially by DriceC1/Drice17

hidGMR.PG has visible phenotype, suppressible | partially by DriceC2/Drice17

hidGMR.PG has visible phenotype, suppressible | partially by DriceS1/Drice17

hidGMR.PG has visible phenotype, suppressible by DriceS2/Drice17

hidGMR.PG has visible phenotype, suppressible | partially by Drice[+]/DriceL1

hidGMR.PG has visible phenotype, suppressible by p535A-1-4

hidGMR.PG has visible phenotype, suppressible | partially by RetGMR.PR

hidGMR.PG/WGMR.PG has visible phenotype, suppressible | partially by morgue126/morgue[+]

hidGMR.PG/WGMR.PG has visible phenotype, suppressible | partially by morgue[+]/morgue457

hidGMR.PG/WGMR.PG has visible phenotype, suppressible | partially by pnut[+]/pnutXP

hidGMR.PG/WGMR.PG has visible phenotype, suppressible | partially by pnut[+]/pnut1

hidGMR.PG/WGMR.PG has visible phenotype, suppressible by klu[+]/kluunspecified

hidGMR.PG/WGMR.PG has visible phenotype, suppressible by glunspecified

hidGMR.PG/WGMR.PG has visible phenotype, suppressible by Df(2R)017/+

hidGMR.PG/WGMR.PG has visible phenotype, suppressible by Df(2R)PC66/+

hidGMR.PG/WGMR.PG has visible phenotype, suppressible by morgue[+]/morgueEP1184/Scer\GAL4[-]

hidGMR.PG/WGMR.PG has increased cell death phenotype, suppressible by morgue[+]/morgueEP1184/Scer\GAL4[-]

hidGMR.PG/WGMR.PG has visible phenotype, suppressible | partially by nmounspecified/nmo[+]

hidGMR.PG/WGMR.PG has visible phenotype, suppressible | partially by eff598/eff[+]

hidGMR.PG/WGMR.PG has visible phenotype, suppressible | partially by eff[+]/effD73

hidGMR.PG/WGMR.PG has visible phenotype, suppressible by Diap133-1s

hidGMR.PG/WGMR.PG has visible phenotype, suppressible by Diap121-4s

hidGMR.PG/WGMR.PG has visible phenotype, suppressible by Df(2L)morgue19/+

hidGMR.PG/WGMR.PG has visible phenotype, suppressible by DarkCD4

NOT suppressed by
Statement
Reference

hidGMR.PG has visible | adult stage phenotype, non-suppressible by axed2094

hidGMR.PG has visible phenotype, non-suppressible by Drice[+]/Drice17

hidGMR.PG/WGMR.PG has visible phenotype, non-suppressible | somatic clone by Sarm896

hidGMR.PG/WGMR.PG has visible phenotype, non-suppressible by yki[+]/ykiB5

hidGMR.PG has visible phenotype, non-suppressible by DJ-1αUAS.cUa/Scer\GAL4GMR.PU

hidGMR.PG/WGMR.PG has visible phenotype, non-suppressible by scnyD.GMR

hidGMR.PG/WGMR.PG has visible phenotype, non-suppressible by DreddB118

hidGMR.PG/WGMR.PG has visible phenotype, non-suppressible by DecayΔK2/DecayΔK2

hidGMR.PG/WGMR.PG has visible | somatic clone phenotype, non-suppressible by DroncI24/Nc[+]

hidGMR.PG/WGMR.PG has visible phenotype, non-suppressible by Darkunspecified/Ark[+]

hidGMR.PG/WGMR.PG has visible phenotype, non-suppressible by Madunspecified

hidGMR.PG/WGMR.PG has visible phenotype, non-suppressible by Stat92Eunspecified

hidGMR.PG/WGMR.PG has visible phenotype, non-suppressible by TER94[+]/TER9426-8

hidGMR.PG/WGMR.PG has visible phenotype, non-suppressible by Darkk11502

Enhancer of
Statement
Reference

hidGMR.PG/WGMR.PG is an enhancer of visible phenotype of Dcp-1fl.GMR

Suppressor of
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by CG8830[+]/DUBAIKG07439

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by smoD16

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Ack86/Ack86

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Rab11mo

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by PSR[+]/PSRFM1

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by PSRFM1/PSRFM1

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Dunspecified

hidGMR.PG/WGMR.PG has eye disc phenotype, enhanceable by hpoBF33

hidGMR.PG/WGMR.PG has phenotype, enhanceable by Diap111-3e

hidGMR.PG/WGMR.PG has phenotype, enhanceable by Diap14

hidGMR.PG/WGMR.PG has phenotype, enhanceable by Diap15

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Diap19

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Diap1SL

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Diap1109.07

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Egfrf2

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Ras85DΔC40B

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Raf11

hidGMR.PG/WGMR.PG has ommatidium phenotype, enhanceable by Raf11

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by rl10a

hidGMR.PG/WGMR.PG has ommatidium phenotype, enhanceable by rl10a

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Dsor1LF133

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Egfrf1

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Ras85De2F

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Raf7

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by rlS-694

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Diap16

hidGMR.PG/WGMR.PG has eye phenotype, enhanceable by Diap18

NOT Enhanced by
Statement
Reference

hidGMR.PG/WGMR.PG has eye phenotype, non-enhanceable by Debcl59

hidGMR.PG/WGMR.PG has eye phenotype, non-enhanceable by Madunspecified

hidGMR.PG/WGMR.PG has eye phenotype, non-enhanceable by Stat92Eunspecified

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by Bruceunspecified/Bruce[+]

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by Df(3R)faf-BP/+

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by Pros26[+]/Prosβ61

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by Ubc2k13206

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by lwrunspecified

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by Dricefl.GMR

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by EM3-1EM3-1

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by SEF2-1

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by SEM2-4

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by SM2-1SM2-1

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by SM3-2SM3-2

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by SM3-3SM3-3

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by SM3-6SM3-6

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by SM3-8SM3-8

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by bulSF3-1

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by stySM3-5

hidGMR.PG/WGMR.PG has phenotype, non-enhanceable by stySM3-9

Suppressed by
Statement
Reference

hidGMR.PG has eye phenotype, suppressible | partially by DroncI29

hidGMR.PG has eye phenotype, suppressible by Drice17/Drice17

hidGMR.PG has eye phenotype, suppressible by DriceΔ1/Drice17

hidGMR.PG has eye phenotype, suppressible by DriceL1/Drice17

hidGMR.PG has eye phenotype, suppressible by DriceL2/Drice17

hidGMR.PG has eye phenotype, suppressible | partially by DriceC1/Drice17

hidGMR.PG has eye phenotype, suppressible | partially by DriceC2/Drice17

hidGMR.PG has eye phenotype, suppressible | partially by DriceS1/Drice17

hidGMR.PG has eye phenotype, suppressible by DriceS2/Drice17

hidGMR.PG has eye phenotype, suppressible | partially by Drice[+]/DriceL1

hidGMR.PG has eye phenotype, suppressible by p535A-1-4

hidGMR.PG has eye phenotype, suppressible | partially by RetGMR.PR

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by ptcC

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by NetAΔ

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by NetBΔ

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Den1EX9

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by morgue126/morgue[+]

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by morgue[+]/morgue457

hidGMR.PG/WGMR.PG has eye | somatic clone phenotype, suppressible by CblK26

hidGMR.PG/WGMR.PG has eye | somatic clone phenotype, suppressible by Cbl8

hidGMR.PG/WGMR.PG has eye | somatic clone phenotype, suppressible by Cbl4

hidGMR.PG/WGMR.PG has eye | somatic clone phenotype, suppressible by CblL31

hidGMR.PG/WGMR.PG has eye | somatic clone phenotype, suppressible by Cbl7

hidGMR.PG has eye phenotype, suppressible by BacA\p35GMR.PH

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkA3b

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkA5

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkA24

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkB5

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkB15

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkC1

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkC4

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkD3

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkD4

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkE4

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkG8

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkG15

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkG29

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkH16

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkH28

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkH36

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkJ15

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkL46

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkN28

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkN52

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkP13

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkP15

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkP46

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkP56

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkS7

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkS9

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkB2

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkI1

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkJ7

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkN5

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkN10

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkA6

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by DarkM20

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Vps25K2

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Vps25N55

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Df(3R)Drice/Drice17

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | somatic clone by matse235

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by lzts1

hidGMR.PG/WGMR.PG has eye | somatic clone phenotype, suppressible by Dronc2/Dronc2

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by pnut[+]/pnut1

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by pnut[+]/pnutXP

hidGMR.PG/WGMR.PG has ommatidium phenotype, suppressible by klu[+]/kluunspecified

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by glunspecified

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Df(2R)017/+

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Df(2R)PC66/+

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by morgue[+]/morgueEP1184/Scer\GAL4[-]

hidGMR.PG/WGMR.PG has ommatidium phenotype, suppressible by morgue[+]/morgueEP1184/Scer\GAL4[-]

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by nmounspecified/nmo[+]

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by eff598/eff[+]

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by eff[+]/effD73

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Diap121-4s

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Diap133-1s

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Df(2L)morgue19/+

hidGMR.PG/WGMR.PG has phenotype, suppressible by Diap121-2s

hidGMR.PG/WGMR.PG has phenotype, suppressible by Diap123-4s

hidGMR.PG/WGMR.PG has phenotype, suppressible by Diap123-8s

hidGMR.PG/WGMR.PG has phenotype, suppressible by Diap145-2s

hidGMR.PG/WGMR.PG has phenotype, suppressible by Diap16-3s

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Diap16B

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Diap181.03

hidGMR.PG/WGMR.PG has phenotype, suppressible | partially by Df(3L)AC1

hidGMR.PG/WGMR.PG has eye phenotype, suppressible | partially by Df(3L)AC1

hidGMR.PG/WGMR.PG has phenotype, suppressible by E(rst)H42H42

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by DarkCD4

hidGMR.PG/WGMR.PG has ommatidium phenotype, suppressible by rlSem

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Diap1GMR.PH

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by RasGAP121-1s

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by sty28-4s

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by aosΔ7

hidGMR.PG/WGMR.PG has ommatidium phenotype, suppressible by aosΔ7

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by EgfrE1

hidGMR.PG/WGMR.PG has ommatidium phenotype, suppressible by EgfrE1

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by Raf::torhs.sev

hidGMR.PG/WGMR.PG has phenotype, suppressible by BacA\p35GMR.PH

hidGMR.PG/WGMR.PG has eye disc phenotype, suppressible by Dsor1Su1

hidGMR.PG/WGMR.PG has eye phenotype, suppressible by rlSu23

hidGMR.PG/WGMR.PG has eye disc phenotype, suppressible by rlSu23

NOT suppressed by
Statement
Reference

hidGMR.PG has eye phenotype, non-suppressible by hrmGD1807/Scer\GAL4GMR.PU

hidGMR.PG has eye phenotype, non-suppressible by Ae2KK100095/Scer\GAL4GMR.PU

hidGMR.PG has eye phenotype, non-suppressible by axed2094

hidGMR.PG has eye phenotype, non-suppressible by Drice[+]/Drice17

hidGMR.PG has eye phenotype, non-suppressible by FakUAS.Tag:HA/Scer\GAL4GMR.PU

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible | somatic clone by Sarm896

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by yki[+]/ykiB5

hidGMR.PG has eye phenotype, non-suppressible by DJ-1αUAS.cUa/Scer\GAL4GMR.PU

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by Debcl59

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible | somatic clone by lsn5F3-8

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by scnyD.GMR

hidGMR.PG has eye phenotype, non-suppressible by FHV\B2UAS.HM/Scer\GAL4GMR.PF

hidGMR.PG has eye phenotype, non-suppressible by Scer\GAL4GMR.PF/Ivir\NS1UAS.HM

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by DreddB118

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by DecayΔK2/DecayΔK2

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by Dronc11/Nc[+]

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by Dronc51/Nc[+]

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by Dronc30/Nc[+]

hidGMR.PG/WGMR.PG has eye | somatic clone phenotype, non-suppressible by DroncI24/Nc[+]

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by Darkunspecified/Ark[+]

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by Madunspecified

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by Stat92Eunspecified

hidGMR.PG/WGMR.PG has eye phenotype, non-suppressible by TER94[+]/TER9426-8

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by Ubc2k13206

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by lwrunspecified

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by EM3-1EM3-1

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by SEF2-1

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by SEM2-4

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by SM2-1SM2-1

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by SM3-2SM3-2

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by SM3-3SM3-3

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by SM3-6SM3-6

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by SM3-8SM3-8

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by bulSF3-1

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by stySM3-5

hidGMR.PG/WGMR.PG has phenotype, non-suppressible by stySM3-9

Enhancer of
Statement
Reference

hidGMR.PG/WGMR.PG is an enhancer of eye phenotype of Dcp-1fl.GMR

NOT Enhancer of
Statement
Reference

hidGMR.PG/WGMR.PG is a non-enhancer of phenotype of Dricefl.GMR

Other
Additional Comments
Genetic Interactions
Statement
Reference

The small eye phenotype resulting from the cell death induced by expression of hidGMR.PG is partially suppressed by combination with DroncI29 but not axed2094.

The strongly reduced eye size characteristic for adult flies expressing hidGMR.PG is partially reverted by expression of either DubaGD11813 or DubaKK108478 under the control of Scer\GAL4GMR.PU or by combination with the Duba107 allele in homozygous state.

Drice17/Drice17, Drice17/DriceΔ1, Drice17/DriceL1, Drice17/DriceL2, Drice17/DriceC1, Drice17/DriceC2, Drice17/DriceS1, Drice17/DriceS2 (but not Drice17/+) significantly suppresses the eye ablation phenotype in hidGMR.PG flies. DriceL1/+ weakly suppresses the eye ablation phenotype in hidGMR.PG flies.

Expression of CorpEY03495 under the control of Scer\GAL4GMR.PF suppresses the increased cell death and reduced eye phenotypes caused by expression of hidGMR.PG.

p535A-1-4 suppresses the reduced eye phenotypes caused by expression of hidGMR.PG.

Expression of CG3251GD10916 under the control of Scer\GAL4GMR.PF suppresses the hidGMR.PG-induced small eye phenotype.

Expression of CG3251KK106465 under the control of Scer\GAL4GMR.PF suppresses the hidGMR.PG-induced small eye phenotype.

Expression of RetGMR.PR partially suppresses the reduction in eye size seen in flies expressing hidGMR.PG. This suppression is partially reversed when FakScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU.

Expression of FakScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU does not have a significant effect on the reduced eye size seen upon expression of hidGMR.PG.

Eyes mosaic for cosH29, cosL51, cosP50, ptcC, ptcL49, Pka-C1K2 or Pka-C1B3 (generated using the ey-FLP/FRT system) moderately suppress the WGMR.PG eye phenotype. This suppression is cell non-autonomous.

Eyes mosaic for smoD16 (generated using the ey-FLP/FRT system) enhance the WGMR.PG eye phenotype.

Eye discs mosaic for cosH29 (generated using the ey-FLP/FRT system) suppress the WGMR.PG cell death phenotype by increasing the apoptosis resistance of neighbouring non-mutant cells - cosH29 clones themselves are unprotected from WGMR.PG-induced apoptosis. This cell non-autonomous suppression occurs only in the first, and not the second, apoptotic wave.

Eyes mosaic for Uba1H42 (generated using the ey-FLP/FRT system) suppress the WGMR.PG eye phenotype. This suppression is cell autonomous.

The suppression of the WGMR.PG eye phenotype seen in eyes mosaic for cosH29 (generated using the ey-FLP/FRT system) is reverted by expression of ciCe-2.Scer\UAS.T:Ivir\HA1 (via the MARCM system) in the cosH29 clones.

The suppression of the WGMR.PG eye phenotype seen in eyes mosaic for cosH29 (generated using the ey-FLP/FRT system) is abrogated by heterozygosity for Df(1)N-8, or both DlRevF10 and SerRX82.

The suppression of the WGMR.PG eye phenotype seen in eyes mosaic for Pka-C1B3 (generated using the ey-FLP/FRT system) is partially reverted if these clones are also mutant for Su(H)del47.

A Cdk7S164A.T170A mutant background significantly suppresses the partial eye ablation found upon expression of WGMR.PG in the developing eye.

NetAΔ partially suppresses the cell death seen in flies expressing WGMR.PG, resulting in increased eye size.

NetBΔ enhances the cell death seen in flies expressing WGMR.PG, resulting in a further reduced eye size.

Df(1)NetABΔ has little effect on the cell death seen in the eye of flies expressing WGMR.PG. Flies continue to have small eyes compared to controls.

Clbn1Q/Clbn1Q does not suppress the induction of apoptosis seen in hidGMR.PG third instar eye discs.

Early third instar larvae expressing shiK44A.Scer\UAS under the control of "BL-Gal4" (a combination of Scer\GAL4elav.PLu, Scer\GAL80tsh-GAL80 and Scer\GAL80Cha.PK) at the restrictive temperature and also carrying WGMR.PG show a normal avoidance response to a spot of intense light.

Expression of BruceBIR.Scer\UAS or BruceScer\UAS.T:Hsap\MYC in the developing eye under the control of Scer\GAL4GMR.PF weakly suppresses the small eye phenotype seen in WGMR.PG mutants.

Homozygous Ect4896 clones fail to suppress the cell death in the eye caused by WGMR.PG.

Expression of AckScer\UAS.cSb under the control of Scer\GAL4GMR.PU greatly suppresses the reduced eye size caused by WGMR.PG.

Expression of AckK156A.Scer\UAS under the control of Scer\GAL4GMR.PU does not modify the reduced eye size caused by WGMR.PG.

Homozygosity for Ack86 enhances the reduced eye size caused by WGMR.PG.

Expression of AckGD8506 under the control of Scer\GAL4GMR.PU enhances the reduced eye size caused by WGMR.PG.

Co-expression of AckScer\UAS.cSb under the control of Scer\GAL4GMR.PU suppresses the increased number of apoptotic cells seen posterior to the second mitotic wave and in the posterior region of the eye disc in the zone of compensatory proliferation in eye discs expressing WGMR.PG.

Co-expression of drkKK109233 does not modify eye size in animals expressing WGMR.PG.

Expression of ykiScer\UAS.cHa under the control of Scer\GAL4GMR.PU suppresses the reduced eye size caused by WGMR.PG and also results in a reduction in pigmentation.

ykiB5/+ does not suppress the reduced eye size caused by WGMR.PG.

Ras85DR68Q suppresses WGMR.PG induced cell death in a dosage-dependent manner.

Eye cell death observed in WGMR.PG flies is suppressed by expression of Den1VDRC.cUa under the control of Scer\GAL4GMR.PF.

Eye cell death observed in WGMR.PG flies is suppressed by expression of CSN5NIG.14884R under the control of Scer\GAL4GMR.PF.

Eye cell death observed in WGMR.PG flies is suppressed by expression of CG1503VDRC.cUa under the control of Scer\GAL4GMR.PF.

Eye cell death observed in WGMR.PG flies is suppressed in a Den1EX9 mutant background.

Expression of DJ-1αScer\UAS.cUa under the control of Scer\GAL4GMR.PU is unable to rescue the eye phenotype of flies expressing hidGMR.PG.

RNAi-mediated knockdown of rpr through expression of rprGD4698 in the developing eye under the control of Scer\GAL4GMR.PF suppresses WGMR.PG-induced eye ablation.

The ectopic eye death seen in flies carrying WGMR.PG is dominantly suppressed by morgue126 and by morgue457.

The eye-ablation phenotype in WGMR.PG animals is suppressed in Vps25N55 somatic clones generated in the eye-antennal imaginal disc in a non-autonomous manner.

The eye-ablation phenotype in WGMR.PG animals is not suppressed in lsn5F3-8 somatic clones generated in the eye-antennal imaginal disc.

The eye-ablation phenotype in WGMR.PG animals is strongly suppressed in Vps36L5212 somatic clones generated in the eye-antennal imaginal disc.

Scer\GAL4GMR.PF-mediated expression of P{Sym-UAS-Hsrω} has a marginal rescue effect on the WGMR.PG eye phenotype.

Scer\GAL4GMR.PF-mediated expression of HsrωEP3037 does not discernibly enhance the WGMR.PG eye phenotype, probably because WGMR.PG eyes are already very damaged.

Expression of spendsRNA.Scer\UAS under the control of Scer\GAL4GMR.PF fails to suppress the reduction in eye size seen in flies expressing WGMR.PG.

Expression of nitodsRNA.Scer\UAS.cCa under the control of Scer\GAL4GMR.PF partially suppresses the reduction in eye size seen in flies expressing WGMR.PG.

Co-expression of nitodsRNA.Scer\UAS.cCa and spendsRNA.Scer\UAS under the control of Scer\GAL4GMR.PF partially suppresses the reduction in eye size seen in flies expressing WGMR.PG. The suppression is greater than is seen when nitodsRNA.Scer\UAS.cCa is expressed alone.

The small eye phenotype caused by WGMR.PG is moderately strongly suppressed by inducing homozygous clones of Uba1D6 in the eye. A reduction in apoptotic cell death is seen in the double mutant eye discs compared to WGMR.PG single mutants, with the suppression occurring in a region specific manner.

The small eye phenotype caused by WGMR.PG is moderately strongly suppressed by inducing homozygous clones of Uba1H33 or Uba1H42 in the eye. The rescued eye tissue is homozygous for the Uba1 mutation in each case, indicating that the suppression is cell autonomous.

The small eye phenotype of WGMR.PG eye clones is suppressed by a homozygous CblK26, Cbl8, Cbl4, CblL31, or Cbl7 background.

Iap2E151 has little if any effect on the eye phenotype caused by WGMR.PG.

Co-expression of PSRScer\UAS.cKa under the control of Scer\GAL4GMR.PF partially suppresses the small rough eye seen in flies expressing WGMR.PG.

The rough eye phenotype caused by WGMR.PG is enhanced by one copy of PSRFM1 and is further enhanced by two copies of PSRFM1.

The loss of eye tissue that is caused by WGMR.PG is partially suppressed if the eye is also homozygous for Uba1B2.

WGMR.PG-induced ablation of the visual system results in rhythmic locomotory activity behaviour in flies expressing Scer\GAL4P2.4.Pdf driven crydsRNA.Scer\UAS.cPa under constant light conditions. Wild-type flies do not show rhythmic behavior under the same conditions.

The WGMR.PG eye ablation phenotype is strongly suppressed when eyes carry homozygous clones for the following mutations: ArkA3b, ArkA5, ArkA24, ArkB5, ArkB15, ArkC1, ArkC4, ArkD3, ArkD4, ArkE4, ArkG8, ArkG15, ArkG29, ArkH16, ArkH28, ArkH36, ArkJ15, ArkL46, ArkN28, ArkN52, ArkP13, ArkP15, ArkP46, ArkP56, ArkS7, ArkS9.

The WGMR.PG eye ablation phenotype is suppressed to a medium degree when eyes carry homozygous clones for the following mutations: ArkB2, ArkI1, ArkJ7, ArkN5, ArkN10.

The WGMR.PG eye ablation phenotype is weakly suppressed when eyes carry homozygous clones for the following mutations: ArkA6, ArkM20.

The elevated apoptosis in WGMR.PG eye discs is significantly reduced when eyes carry homozygous ArkG8 clones.

The small eye phenotype generated by WGMR.PG is not suppressed by expression of either the CtBPGSA132 or the CtBPGSA396 transgene (both under the control of Scer\GAL4GMR.PF).

Vps25K2 moderate-strongly suppresses the hidGMR.PG eye phenotype.

Vps25N55 moderate-strongly suppresses the hidGMR.PG eye phenotype.

While overexpression of upd1Scer\UAS.cZa in the eye gives rise to enlarged eyes, it is not sufficient to suppress hidGMR.PG.

The reduction in adult eye size caused by expression of WGMR.PG is suppressed if the eye is made homozygous for NcΔA8 (using the eyFLP method).

The reduction in adult eye size caused by expression of WGMR.PG is suppressed in a IceΔ2C8/IceΔ2C8 background.

The reduction in adult eye size caused by expression of WGMR.PG is not suppressed in a decayΔK2/decayΔK2 or DreddB118 background.

The reduction in adult eye size caused by expression of WGMR.PG is not suppressed if the eye is made homozygous for Dcp-1Prev1 (using the eyFLP method).

The apoptosis posterior to the morphogenetic furrow that is induced by WGMR.PG in third larval instar eye discs is completely suppressed in a NcΔA8/NcΔA8 background.

The apoptosis posterior to the morphogenetic furrow that is induced by WGMR.PG in third larval instar eye discs is almost completely suppressed in a IceΔ2C8/IceΔ2C8 background.

A WGMR.PG background, used to eliminate all heterozygous and wild-type cells in the developing eye, Upf214J cells proliferate, differentiate, and form an eye, although the eyes are smaller and more disorganised (rougher) than those of controls.

The small eye phenotype exhibited by flies expressing WGMR.PG is partially suppressed in a IceΔ1 homozygous background.

The small, rough eye phenotype of WGMR.PG flies is partially suppressed by the expression of mir-278KN448.mirvana-1.Scer\UAS under the control of Scer\GAL4GMR.PF and strongly suppressed by mir-278KN447.Scer\UAS under the control of Scer\GAL4GMR.PF.

The eye phenotype of flies expressing WGMR.PG is not enhanced by a mir-278mirvana-1 or a mir-278mirvana-1/Df(2R)Exel7137 background.

Homozygous Ice17 clones induced in the eye suppress the eye ablation phenotype caused by WGMR.PG.

The eye ablation phenotype caused by WGMR.PG is suppressed if the flies are also carrying Ice17/Ice17 or Ice17/Df(3R)Ice.

The suppression is even stronger in Ice17 homozygous flies.

The creation of matse325 clones in the eye, significantly suppress the cell death and small eye phenotypes seen in matse325 animals.

The rough, small eye phenotype of WGMR.PG is not suppressed by Nc11/+, Nc51/+ or Nc30/+.

Reducing lz activity by transferring lzts1 WGMR.PG flies to the non-permissive temperature of 33oC partially suppresses the WGMR.PG eye phenotype.

The severity of the WGMR.PG eye phenotype is suppressed by "dronc[d5]" animals (Df(3L)NcZ in which CG6685 function, but not Nc function, is rescued by P{CG6685+tDa}).

The reduced eye phenotype caused by expression of WGMR.PG is significantly suppressed by pnut1/+ or pnutXP/+, but Arkunspecified/+ has little effect.

WGMR.PG; cryb flies fail to entrain to light-dark cycles of even the highest amplitude.

WGMR.PG; cryb flies show anomalous rhythmicity in when kept in constant light, like cryb flies.

WGMR.PG; Pdf01 flies show similar weak short-period rhythmicity phenotypes when kept in constant darkness to Pdf01 single mutant flies.

kluunspecified/+ strongly suppresses the eye phenotype caused by WGMR.PG; the adult eye is dramatically increased in size and the pattern of the ommatidia is almost normal.

Eye size is largely restored by co-expression of banEP3622 (driven by Scer\GAL4GMR.PF) with WGMR.PG. The addition of Df(3L)banΔ1 to WGMR.PG animals leads to a significant enhancement of the eye phenotype.

When scrib1 clones are made in eyes expressing WGMR.PG the viability of the mutant clones increases dramatically. This results in tissue overgrowth and lethality.

When hpoBF33 clones are made in a WGMR.PG background the resultant eyes are larger than that seen in WGMR.PG animals alone.

WGMR.PG-induced apoptosis is blocked in hpodsRNA.Scer\UAS mutant clones.

Heterozygosity for nmounspecified partially rescues the small eye size of WGMR.PG animals.

The addition of WGMR.PG to th5 heterozygotes leads to an enhancement of cell killing. The subsequent addition of ArkCD4/ArkCD4 suppresses that enhancement.

The eye ablation phenotype of WGMR.PG flies is partially suppressed by effD73/+.

When sav3 clones are induced in the eye disc in WGMR.PG mutants, the induction of apoptosis is reduced in a cell autonomous manner.

The ablated eye phenotype of rprGMR.PW flies is suppressed by th21-4s or th33-1s.

The eye cell death phenotype caused by WGMR.PG is suppressed by Df(2L)morgue19/+.

The WGMR.PG severely ablated eye phenotype is significantly suppressed by DammC156G.GMR.T:Zzzz\FLAG.

The addition of Icefl.GMR to WGMR.PG produces no enhancement of either phenotype instead producing an additive effect. The addition of WGMR.PG to Dcp-1fl.GMR flies show a weak enhancement of the eye phenotype seen in these flies.

The eye phenotype caused by expression of WGMR.PG is not affected by Arkk11502.

The WGMR.PG eye phenotype is markedly suppressed if the flies are also homozygous for ArkCD4.

Arkk11502 has little effect on the eye phenotype caused by WGMR.PG.

The reduced eye phenotype is markedly suppressed by Dsor1Su1 and rlSu23. The larval eye disc phenotype is also reduced in Dsor1Su1 and rlSu23 mutants.

The small eye phenotype is dominantly enhanced by th mutations.

Xenogenetic Interactions
Statement
Reference

Co-expression of BacA\p35GMR.PH completely suppresses the reduced eye size caused by WGMR.PG.

Expression of FHV\B2Scer\UAS.HM in the developing eye, under the control of Scer\GAL4GMR.PF fails to suppress the small, rough eye phenotype of hidGMR.PG.

Expression of Zzzz\B2Scer\UAS.HM in the developing eye, under the control of Scer\GAL4GMR.PF fails to suppress the small, rough eye phenotype of hidGMR.PG.

Expression of Zzzz\E3LScer\UAS.HM in the developing eye, under the control of Scer\GAL4GMR.PF fails to suppress the small, rough eye phenotype of hidGMR.PG.

Expression of Zzzz\p19Scer\UAS.HM in the developing eye, under the control of Scer\GAL4GMR.PF fails to suppress the small, rough eye phenotype of hidGMR.PG.

Expression of Ivir\NS1Scer\UAS.HM in the developing eye, under the control of Scer\GAL4GMR.PF fails to suppress the small, rough eye phenotype of hidGMR.PG.

Expression of BacA\p35GMR.PH in the developing eye suppresses the small, rough eye phenotype of hidGMR.PG.

Complementation and Rescue Data
Comments

RNAi-mediated knockdown of W through expression of WGD1673 in the developing eye under the control of Scer\GAL4GMR.PF suppresses WGMR.PG-induced eye ablation.

Images (0)
Mutant
Wild-type
Stocks (15)
Notes on Origin
Discoverer
Comments
Comments

The ability of W to kill cells appears to be cell-autonomous.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
WGMR.PG
WGMR.PHb
hidGMR.PG
Name Synonyms
glass multimer reporter construct of Grether
Secondary FlyBase IDs
  • FBal0045285
  • FBal0194620
References (151)