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General Information
Symbol
Dmel\mir-8SC1
Species
D. melanogaster
Name
FlyBase ID
FBal0265087
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Insertion 1.1kb from the mir-8 gene.

    Insertion components
    P{GS-un}mir-8SC1
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Expression of mir-8SC1 under the control of Scer\GAL4Bx-MS1096 results in a small wing phenotype.

    Expression of mir-8SC1 under the control of Scer\GAL4vg.PU results in a nicked wing phenotype.

    Scer\GAL4[h.PU]Expression of mir-8SC1 under the control of Scer\GAL4h.PU results in denticle belt defects in the embryo.

    Expression of mir-8SC1 under the control of Scer\GAL4ey.PH results in eyes with a very reduced ventral region and a profoundly distorted dorsal/ventral boundary. Apoptosis is seen in the ventral region of the eye disc during the first larval instar stage and in the organiser region of the eye disc at the late third larval instar stage in these animals.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    Scer\GAL4ey.PH, mir-8SC1 has visible phenotype, enhanceable by Ser[+]/SerRX106

    Suppressed by
    Statement
    Reference
    NOT suppressed by
    Statement
    Reference
    Suppressor of
    Statement
    Reference
    Other
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    Scer\GAL4ey.PH, mir-8SC1 has eye phenotype, enhanceable by Ser[+]/SerRX106

    Suppressed by
    NOT suppressed by
    Statement
    Reference
    Suppressor of
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Flies expressing DlScer\UAS.cDa under the control of Scer\GAL4ey.PH and also carrying the P{GSV1}lolaGS88A8 insertion (which causes overexpression of psq and lola) show an eye tumour phenotype. In addition, distant metastasis in the thorax and abdomen is seen in 15% of cases. Co-expression of mir-8SC1 significantly reduces the primary eye tumour size, completely inhibits the incidence of metastases and results in a high incidence of adult lethality.

    Co-expression of SerScer\UAS.cSa suppresses the loss of ventral eye tissue caused by expression of mir-8SC1 under the control of Scer\GAL4ey.PH.

    Co-expression of GugScer\UAS.cCa does not suppress the loss of ventral eye tissue caused by expression of mir-8SC1 under the control of Scer\GAL4ey.PH.

    SerRX106/+ markedly enhances the loss of eye tissue caused by expression of mir-8SC1 under the control of Scer\GAL4ey.PH.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    mir-8SC1
    Name Synonyms
    Secondary FlyBase IDs
      References (1)