UASp regulatory sequences drive expression of wild type Hsap\SPTBN2 tagged with Tag:MYC.
Expression of Hsap\SPTBN2Scer\UAS.P\T.T:Hsap\MYC under the control of Scer\GAL4GMR.PF results in a very mild ommatidial phenotype that does not disrupt normal eye development and is similar to control flies. No retinal disorganisation is observed in 10 day old flies and external eye morphology and pigmentation appear normal by 30 days.
Third instar larvae expressing Hsap\SPTBN2Scer\UAS.P\T.T:Hsap\MYC under the control of Scer\GAL4elav.PU do not show a reduced bouton number at the neuromuscular junction per muscle area compared to controls. 5% of third instar larvae carrying two copies of the transgene exhibit a "tail-flip" crawling phenotype due to paralysis of the posterior segments of the body. A similar proportion exhibit this phenotype when one copy of the transgene is present.