Allele Dmel\Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG}

General Information
Symbol	Dmel\Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG}	Species	D. melanogaster
Name		FlyBase ID	FBal0265574
Feature type	allele	Associated gene	Dmel\Tao

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion, in vitro construct - amino acid replacement
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Sato et al., 2007) in vitro construct - coding region fusion (Sato et al., 2007) in vitro construct - regulatory fusion (Sato et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences and P\T promoter sequences drive expression of a mutant form or Tao-1 in which the aspartate at residue 168 has been replaced by an alanine. The construct is tagged with T:Zzzz\FLAG. (Sato et al., 2007)
Carried in construct	P{UASp-Tao.D168A.FLAG} (Sato et al., 2007, Poon et al., 2011)
Tagged with	T:Zzzz\FLAG (Sato et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	fertile, with Scer\GAL4^{nos.UTR.T:Hsim\VP16} (Sato et al., 2007)
Phenotype Manifest In

Detailed Description
	Statement Reference The wings of flies expressing Tao[D168A.Scer\UAS.P\T.T:Zzzz\FLAG] under the control of Scer\GAL4[hh.PU] are a similar size to controls. Expression of Tao[D168A.Scer\UAS.P\T.T:Zzzz\FLAG] under the control of Scer\GAL4[GMR.PF] is unable to enhance the decrease in eye size seen when wts[GMR.PT] and sav[GMR.PT] are co-expressed. (Poon et al., 2011) The amount of pole cell apoptosis seen when Tao-1[D168A.Scer\UAS.P\T.T:Zzzz\FLAG] is expressed under the control of Scer\GAL4[nos.UTR.T:Hsim\VP16] is comparable to controls. (Sato et al., 2007)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement Reference Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG}/Scer\GAL4^GMR.PF is a non-enhancer of size defective \| adult stage phenotype of sav^GMR.PT, wts^GMR.PT (Poon et al., 2011) Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG}/Scer\GAL4^GMR.PF is a non-enhancer of visible \| adult stage phenotype of sav^GMR.PT, wts^GMR.PT (Poon et al., 2011)
Suppressor of
Statement Reference Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor \| partially of increased cell death \| maternal effect \| embryonic stage 13 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor \| partially of increased cell death \| maternal effect \| embryonic stage 14 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor \| partially of increased cell death \| maternal effect \| embryonic stage 15 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor \| partially of increased cell death \| maternal effect \| embryonic stage 16 phenotype of nos^BN (Sato et al., 2007)
Phenotype Manifest In
NOT Enhancer of
Statement Reference Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG}/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of sav^GMR.PT, wts^GMR.PT (Poon et al., 2011)
Suppressor of
Statement Reference Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor \| partially of pole cell \| maternal effect \| embryonic stage 13 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor \| partially of pole cell \| maternal effect \| embryonic stage 14 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor \| partially of pole cell \| maternal effect \| embryonic stage 15 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor \| partially of pole cell \| maternal effect \| embryonic stage 16 phenotype of nos^BN (Sato et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference Expression of Tao-1[D168A.Scer\UAS.P\T.T:Zzzz\FLAG] under the control of Scer\GAL4[nos.UTR.T:Hsim\VP16] suppresses the pole cell apoptosis seen in stage 13-16 embryos derived from nos[BN] females. (Sato et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Tao-1^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Poon et al., 2011, Dev. Cell 21(5): 896--906 The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. [FBrf0216620] Sato et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104(18): 7455--7460 Maternal Nanos represses hid/skl-dependent apoptosis to maintain the germ line in Drosophila embryos. [FBrf0200950]

Allele Dmel\TaoD168A.Scer\UAS.P\T.T:Zzzz\FLAG

Allele Dmel\Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG}