Allele Dmel\Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}

General Information
Symbol	Dmel\Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}	Species	D. melanogaster
Name		FlyBase ID	FBal0265575
Feature type	allele	Associated gene	Dmel\Tao

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Sato et al., 2007) in vitro construct - regulatory fusion (Sato et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences and P\T promoter sequences drive expression of Tao-1 tagged with T:Zzzz\FLAG. (Sato et al., 2007)
Carried in construct	P{UASp-Tao.FLAG} (Sato et al., 2007, Poon et al., 2011, Boggiano et al., 2011)
Tagged with	T:Zzzz\FLAG (Sato et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	size defective \| adult stage, with Scer\GAL4^hh.PU (Poon et al., 2011) size defective \| adult stage, with Scer\GAL4^rn-GAL4-5 (Poon et al., 2011) visible \| adult stage, with Scer\GAL4^hh.PU (Poon et al., 2011) visible \| adult stage, with Scer\GAL4^rn-GAL4-5 (Poon et al., 2011)
Phenotype Manifest In
	wing \| posterior, with Scer\GAL4^hh.PU (Poon et al., 2011) wing \| posterior, with Scer\GAL4^rn-GAL4-5 (Poon et al., 2011)
Detailed Description
	Statement Reference Expression of Tao[Scer\UAS.P\T.T:Zzzz\FLAG] under the control of Scer\GAL4[hh.PU] results in a 14% reduction in the size of the posterior compartment of the wing. Expression of Tao[Scer\UAS.P\T.T:Zzzz\FLAG] under the control of Scer\GAL4[rn-GAL4-5] also results in a reduction in wing size, but also produces wing scalloping. Expression of Tao[Scer\UAS.P\T.T:Zzzz\FLAG] under the control of Scer\GAL4[GMR.PF] does not obviously affect eye size. (Poon et al., 2011) The amount of pole cell apoptosis seen when Tao-1[Scer\UAS.P\T.T:Zzzz\FLAG] is expressed under the control of Scer\GAL4[nos.UTR.T:Hsim\VP16] is comparable to controls. (Sato et al., 2007)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, nos^BN has increased cell death \| maternal effect \| embryonic stage 13 phenotype, suppressible by W⁰⁵⁰¹⁴/Df(3L)H99 (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, nos^BN has increased cell death \| maternal effect \| embryonic stage 14 phenotype, suppressible by W⁰⁵⁰¹⁴/Df(3L)H99 (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, nos^BN has increased cell death \| maternal effect \| embryonic stage 15 phenotype, suppressible by W⁰⁵⁰¹⁴/Df(3L)H99 (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, nos^BN has increased cell death \| maternal effect \| embryonic stage 16 phenotype, suppressible by W⁰⁵⁰¹⁴/Df(3L)H99 (Sato et al., 2007)
Enhancer of
Statement Reference Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is an enhancer of increased cell death \| maternal effect \| embryonic stage 13 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is an enhancer of increased cell death \| maternal effect \| embryonic stage 14 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is an enhancer of increased cell death \| maternal effect \| embryonic stage 15 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is an enhancer of increased cell death \| maternal effect \| embryonic stage 16 phenotype of nos^BN (Sato et al., 2007) Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}/Scer\GAL4^GMR.PF is an enhancer of size defective \| adult stage phenotype of sav^GMR.PT, wts^GMR.PT (Poon et al., 2011) Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}/Scer\GAL4^GMR.PF is an enhancer of visible \| adult stage phenotype of sav^GMR.PT, wts^GMR.PT (Poon et al., 2011)
Suppressor of
Statement Reference Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of size defective \| adult stage phenotype of Scer\GAL4^en-e16E, d^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} (Poon et al., 2011) Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of size defective \| adult stage phenotype of Scer\GAL4^en-e16E, ex^GD12782 (Poon et al., 2011) Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of size defective \| adult stage phenotype of Scer\GAL4^en-e16E, ft^KK101190 (Poon et al., 2011) Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of size defective \| adult stage phenotype of Scer\GAL4^en-e16E, kibra^KK111409 (Poon et al., 2011) Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of visible \| adult stage phenotype of Scer\GAL4^en-e16E, d^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} (Poon et al., 2011) Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of visible \| adult stage phenotype of Scer\GAL4^en-e16E, ex^GD12782 (Poon et al., 2011) Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of visible \| adult stage phenotype of Scer\GAL4^en-e16E, ft^KK101190 (Poon et al., 2011) Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of visible \| adult stage phenotype of Scer\GAL4^en-e16E, kibra^KK111409 (Poon et al., 2011) Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, Scer\GAL4^hh.PU is a suppressor of size defective \| adult stage phenotype of Mer^NIG.14228R, Scer\GAL4^hh.PU (Poon et al., 2011) Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, Scer\GAL4^hh.PU is a suppressor of visible \| adult stage phenotype of Mer^NIG.14228R, Scer\GAL4^hh.PU (Poon et al., 2011)
NOT Suppressor of
Statement Reference Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, Scer\GAL4^en-e16E is a non-suppressor of size defective \| adult stage phenotype of Pten^{dsRNA.Exel.Scer\UAS}, Scer\GAL4^en-e16E (Poon et al., 2011) Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, Scer\GAL4^en-e16E is a non-suppressor of visible \| adult stage phenotype of Pten^{dsRNA.Exel.Scer\UAS}, Scer\GAL4^en-e16E (Poon et al., 2011)
Phenotype Manifest In
Suppressed by
Statement Reference Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, nos^BN has pole cell \| maternal effect \| embryonic stage 13 phenotype, suppressible by W⁰⁵⁰¹⁴/Df(3L)H99 (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, nos^BN has pole cell \| maternal effect \| embryonic stage 14 phenotype, suppressible by W⁰⁵⁰¹⁴/Df(3L)H99 (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, nos^BN has pole cell \| maternal effect \| embryonic stage 15 phenotype, suppressible by W⁰⁵⁰¹⁴/Df(3L)H99 (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, nos^BN has pole cell \| maternal effect \| embryonic stage 16 phenotype, suppressible by W⁰⁵⁰¹⁴/Df(3L)H99 (Sato et al., 2007)
Enhancer of
Statement Reference Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is an enhancer of pole cell \| maternal effect \| embryonic stage 13 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is an enhancer of pole cell \| maternal effect \| embryonic stage 14 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is an enhancer of pole cell \| maternal effect \| embryonic stage 15 phenotype of nos^BN (Sato et al., 2007) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is an enhancer of pole cell \| maternal effect \| embryonic stage 16 phenotype of nos^BN (Sato et al., 2007) Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of sav^GMR.PT, wts^GMR.PT (Poon et al., 2011)
Suppressor of
Statement Reference Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of wing \| posterior phenotype of Scer\GAL4^en-e16E, d^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} (Poon et al., 2011) Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of wing \| posterior phenotype of Scer\GAL4^en-e16E, ex^GD12782 (Poon et al., 2011) Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of wing phenotype of Scer\GAL4^en-e16E, ft^KK101190 (Poon et al., 2011) Scer\GAL4^en-e16E/Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} is a suppressor of wing phenotype of Scer\GAL4^en-e16E, kibra^KK111409 (Poon et al., 2011) Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, Scer\GAL4^hh.PU is a suppressor of wing \| posterior phenotype of Mer^NIG.14228R, Scer\GAL4^hh.PU (Poon et al., 2011)
NOT Suppressor of
Statement Reference Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}, Scer\GAL4^en-e16E is a non-suppressor of wing phenotype of Pten^{dsRNA.Exel.Scer\UAS}, Scer\GAL4^en-e16E (Poon et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference Expression of Tao[Scer\UAS.P\T.T:Zzzz\FLAG] reduces the wing overgrowth seen when Mer[NIG.14228R] is expressed under the control of Scer\GAL4[hh.PU]. Expression of Tao[Scer\UAS.P\T.T:Zzzz\FLAG] reduces the wing overgrowth seen when ex[GD12782] is expressed under the control of Scer\GAL4[en-e16E]. Expression of Tao[Scer\UAS.P\T.T:Zzzz\FLAG] reduces the wing overgrowth seen when kibra[KK111409] is expressed under the control of Scer\GAL4[en-e16E]. Expression of Tao[Scer\UAS.P\T.T:Zzzz\FLAG] reduces the wing overgrowth seen when ft[KK101190] is expressed under the control of Scer\GAL4[en-e16E]. Expression of Tao[Scer\UAS.P\T.T:Zzzz\FLAG] reduces the wing overgrowth seen when d[Scer\UAS.T:SV5\V5,T:Zzzz\His6] is expressed under the control of Scer\GAL4[en-e16E]. Expression of Tao[Scer\UAS.P\T.T:Zzzz\FLAG] is unable to suppress the wing overgrowth seen when Pten[dsRNA.Exel.Scer\UAS] is expressed under the control of Scer\GAL4[en-e16E]. Expression of Tao[Scer\UAS.P\T.T:Zzzz\FLAG] under the control of Scer\GAL4[GMR.PF] enhances the decrease in eye size seen when wts[GMR.PT] and sav[GMR.PT] are co-expressed. (Poon et al., 2011) Expression of Tao-1[Scer\UAS.P\T.T:Zzzz\FLAG] under the control of Scer\GAL4[nos.UTR.T:Hsim\VP16] enhances the pole cell apoptosis seen in stage 13-16 embryos derived from nos[BN] females. Removal of zygotic W (W[05014]/Df(3L)H99) suppresses the pole cell apoptosis seen when Tao-1[Scer\UAS.P\T.T:Zzzz\FLAG] is expressed under the control of Scer\GAL4[nos.UTR.T:Hsim\VP16] in stage 13-16 embryos derived from nos[BN] females. (Sato et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Tao-1^{Scer\UAS.P\T.T:Zzzz\FLAG} Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Boggiano et al., 2011, Dev. Cell 21(5): 888--895 Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. [FBrf0217346] Poon et al., 2011, Dev. Cell 21(5): 896--906 The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. [FBrf0216620] Sato et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104(18): 7455--7460 Maternal Nanos represses hid/skl-dependent apoptosis to maintain the germ line in Drosophila embryos. [FBrf0200950]

Allele Dmel\TaoScer\UAS.P\T.T:Zzzz\FLAG

Allele Dmel\Tao^{Scer\UAS.P\T.T:Zzzz\FLAG}