Allele Dmel\Caf1^short

General Information
Symbol	Dmel\Caf1^short	Species	D. melanogaster
Name		FlyBase ID	FBal0265622
Feature type	allele	Associated gene	Dmel\Caf1

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q79@. (Anderson et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	increased cell death \| somatic clone \| third instar larval stage (Anderson et al., 2011) lethal (with Caf1^long) (Anderson et al., 2011) lethal (with Caf1^med) (Anderson et al., 2011) lethal (with Df(3R)ED5664) (Anderson et al., 2011) lethal \| first instar larval stage (Anderson et al., 2011) lethal \| second instar larval stage (Anderson et al., 2011) visible \| cold sensitive (with Caf1^med), with Caf1^Scer\UAS.cAa, Scer\GAL4^Ubi (Anderson et al., 2011) visible \| somatic clone (Anderson et al., 2011)
Phenotype Manifest In
	adult head \| somatic clone (Anderson et al., 2011) arista \| cold sensitive (with Caf1^med), with Caf1^Scer\UAS.cAa, Scer\GAL4^Ubi (Anderson et al., 2011) eye \| cold sensitive (with Caf1^med), with Caf1^Scer\UAS.cAa, Scer\GAL4^Ubi (Anderson et al., 2011) eye \| somatic clone (Anderson et al., 2011) eye disc \| somatic clone \| third instar larval stage (Anderson et al., 2011) leg \| ectopic \| cold sensitive (with Caf1^med), with Caf1^Scer\UAS.cAa, Scer\GAL4^Ubi (Anderson et al., 2011) rhabdomere \| cold sensitive (with Caf1^med), with Caf1^Scer\UAS.cAa, Scer\GAL4^Ubi (Anderson et al., 2011)
Detailed Description
	Statement Reference Homozygous larvae appear grossly normal but mature slowly and die as first or second instars. Homozygous clones induced using hs-FLP do not survive in adults. Homozygous clones in the eye which have been generated using the ey-FLP; FRT cell lethal system are very small, comprising only a small portion of the eye. The remaining eye is small, highly disorganised and almost completely devoid of bristles. Approximately 20% of flies containing ey-FLP induced clones have extra or missing appendages on the head, including the ocelli, antennae and maxillary palps. Homozygous clones in the third larval instar eye disc which have been generated using the ey-FLP; FRT cell lethal system are small, show extensive apoptosis and have an irregular arrangement of photoreceptor clusters. Homozygous clones have not been recovered in the adult thorax. Caf1[short]/Caf1[med] flies expressing Caf1[Scer\UAS.cAa] under the control of Scer\GAL4[Ubi] and raised at 18[o]C during the third larval instar stage have disorganised kidney-shaped eyes with abnormalities in the arrangement of rhabdomeres (including loss of small central rhabdomeres) and show homeotic transformation of the arista to leg-like structures that occasionally end in claws. These defects are not seen if the animals are raised at 25[o]C during the third larval instar stage. (Anderson et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Caf1^short/Caf1[+] is a suppressor \| partially of visible \| dominant phenotype of Pc¹⁵ (Anderson et al., 2011) Caf1^short/Caf1[+] is a suppressor of visible phenotype of Scer\GAL4^lz-gal4, sens^Scer\UAS.cNa (Anderson et al., 2011)
Phenotype Manifest In
Suppressor of
Statement Reference Caf1^short/Caf1[+] is a suppressor \| partially of mesothoracic leg phenotype of Pc¹⁵ (Anderson et al., 2011) Caf1^short/Caf1[+] is a suppressor \| partially of metathoracic leg phenotype of Pc¹⁵ (Anderson et al., 2011) Caf1^short/Caf1[+] is a suppressor \| partially of sex comb \| ectopic phenotype of Pc¹⁵ (Anderson et al., 2011) Caf1^short/Caf1[+] is a suppressor of eye phenotype of Scer\GAL4^lz-gal4, sens^Scer\UAS.cNa (Anderson et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference The mutant eye phenotype caused by expression of sens[Scer\UAS.cNa] under the control of Scer\GAL4[lz-gal4] is dominantly suppressed by Caf1[short]. Only 12.3% of Pc[15]/Caf1[short] double heterozygous males have ectopic sex combs on either the second or third leg. (Anderson et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Caf1^med/Caf1^short is rescued by Caf1^+t12 (Anderson et al., 2011) Caf1^short/Caf1^long is rescued by Scer\GAL4^Ubi/Caf1^Scer\UAS.cAa (Anderson et al., 2011) Caf1^short/Df(3R)ED5664 is rescued by Caf1^+t12 (Anderson et al., 2011)
Partially rescued by	Caf1^med/Caf1^short is partially rescued by Scer\GAL4^Ubi/Caf1^Scer\UAS.cAa (Anderson et al., 2011) Caf1^short is partially rescued by Scer\GAL4^Ubi/Caf1^Scer\UAS.cAa (Anderson et al., 2011, Anderson et al., 2011)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Caf1^short (Anderson et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Anderson et al., 2011, Development 138(10): 1957--1966 The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development. [FBrf0213580]

Allele Dmel\Caf1short

Allele Dmel\Caf1^short