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General Information
Symbol
Dmel\Rae1EX28
Species
D. melanogaster
Name
FlyBase ID
FBal0265658
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{GawB}NP3499 (located ~400bp upstream of the first Rae1 exon) generates an approximate 900bp deletion ranging from just before the first exon of Rae1 (including almost the entire Rae1 promoter) to the end of adjacent pirk.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Rae1EX28 mutants survive until the second instar larval stage. The mutant larvae start wandering with a body size close to second instar. They continue to wander for several days without a further increase in their body size and eventually die before pupation.

Rae1EX28 and Rae1EX28/Df(2R)XE-2900 mutant neuromuscular junctions exhibit synaptic terminal overgrowth and decreased bouton size in synapses on muscle 6/7. The average muscle size in these mutants appears similar to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

Rae1EX28 has synapse phenotype, suppressible by wnd3

Rae1EX28 has NMJ bouton phenotype, suppressible by wnd3

Rae1EX28 has synapse phenotype, suppressible by Atg13/Atg1[+]

Rae1EX28 has NMJ bouton phenotype, suppressible by Atg13/Atg1[+]

Rae1EX28 has synapse phenotype, suppressible by Atg2[+]/Atg2EP3697

Rae1EX28 has NMJ bouton phenotype, suppressible by Atg2[+]/Atg2EP3697

Rae1EX28 has synapse phenotype, suppressible by Atg18aKG03090/Atg18[+]

Rae1EX28 has NMJ bouton phenotype, suppressible by Atg18aKG03090/Atg18[+]

NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference

Rae1[+]/Rae1EX28 is an enhancer of synapse phenotype of hiwND51

Rae1[+]/Rae1EX28 is an enhancer of NMJ bouton phenotype of hiwND51

Additional Comments
Genetic Interactions
Statement
Reference

A wnd3 background suppresses the bouton number increase and the reduction in bouton size seen in Rae1EX28 mutants.

Presynaptic expression of hiwScer\UAS.W.T:Avic\GFP-EGFP under the control of Scer\GAL4elav-C155 fails to rescue the bouton number increase found in Rae1EX28 mutant synapses.

An Atg13 heterozygous background dominantly suppresses the increase in bouton number seen in Rae1EX28 homozygous mutant neuromuscular junction.

An Atg2EP3697 heterozygous background dominantly suppresses the increase in bouton number seen in Rae1EX28 homozygous mutant neuromuscular junction.

An Atg18KG03090 heterozygous background dominantly suppresses the increase in bouton number seen in Rae1EX28 homozygous mutant neuromuscular junction.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)