Allele Dmel\cd^Y459X

General Information
Symbol	Dmel\cd^Y459X	Species	D. melanogaster
Name		FlyBase ID	FBal0265698
Feature type	allele	Associated gene	Dmel\cd

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Y459@. (Harris et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Mutant flies show a significant reduction in ommochrome pigment levels compared to wild type. (Harris et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference cd^Y459X is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, aos^GD16463 (Harris et al., 2011)
Phenotype Manifest In
Enhancer of
Statement Reference cd^Y459X is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, aos^GD16463 (Harris et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference The mispatterning of the eye caused by expression of aos[GD16463] under the control of Scer\GAL4[GMR.PF] is enhanced in a cd[Y459X] background. (Harris et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	cd^Y459X is rescued by cd^{Scer\UAS.P\T.cHa}/Scer\GAL4^GMR.PF (Harris et al., 2011) cd^Y459X is rescued by cd^{Scer\UAS.P\T.T:Avic\GFP-EGFP}/Scer\GAL4^GMR.PF (Harris et al., 2011)
Comments	Expression of cd[Scer\UAS.P\T.cHa] or cd[Scer\UAS.P\T.T:Avic\GFP-EGFP] under the control of Scer\GAL4[GMR.PF] rescues the reduction in ommochrome pigment levels that is seen in cd[Y459X] flies. (Harris et al., 2011)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cd^Y459X (Harris et al., 2011) cd^Y495X (Harris et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Harris et al., 2011, J. Cell Biol. 194(1): 77--87 Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing. [FBrf0214287]

Allele Dmel\cdY459X

Allele Dmel\cd^Y459X