A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\zyd1

General Information
SymbolDmel\zyd1SpeciesD. melanogaster
NameFlyBase IDFBal0265774
Feature typealleleAssociated geneDmel\zyd
Allele class
Mutagenethyl methanesulfonate
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Description
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FB2013_03
Genes
zyd
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Melom and Littleton, 2013)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Amino acid replacement: W475@.
(Melom and Littleton, 2013)
Cytology
hide Phenotypic Data
hide Phenotypic Class
bang sensitive
(Melom and Littleton, 2013)
bang sensitive (with zyd2)
(Melom and Littleton, 2013)
bang sensitive (with zyd3)
(Melom and Littleton, 2013)
behavior defective | adult stage | recessive | heat sensitive
(Melom and Littleton, 2013)
behavior defective | third instar larval stage | heat sensitive
(Melom and Littleton, 2013)
neurophysiology defective | third instar larval stage | heat sensitive
(Melom and Littleton, 2013)
viable
(Melom and Littleton, 2013)
hide Phenotype Manifest In
hide Detailed Description
Statement
Reference
Homozygotes show rapid seizures upon exposure to 38[o]C. Homozygous larvae also show seizures at 38[o]C and the central pattern generator output from the neuromuscular junction shows rapid, unpatterned firing, in contrast to controls, which retain motor neuron bursting necessary for normal crawling behaviour. At room temperature, homozygous, hemizygous, zyd[1]/zyd[2] and zyd[1]/zyd[3] adults show a bang-sensitive phenotype (seizures and temporary paralysis in response to brief vortexing). Homozygotes show robust seizures after a brief period of anesthesia on ice.
(Melom and Littleton, 2013)
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Linkouts
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hideSuppressed by
Statement
Reference
zyd1 has behavior defective | recessive | adult stage | heat sensitive phenotype, suppressible by CamHMS01318/Scer\GAL4repo
(Melom and Littleton, 2013)
zyd1 has neurophysiology defective | third instar larval stage | heat sensitive phenotype, suppressible by CamHMS01318/Scer\GAL4repo
(Melom and Littleton, 2013)
hide Phenotype Manifest In
hide Additional Comments
hide Genetic Interactions
Statement
Reference
The temperature-sensitive seizure phenotype of zyd[1] larvae and adults is completely suppressed by expression of Cam[HMS01318] under the control of Scer\GAL4[repo].
(Melom and Littleton, 2013)
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Rescued by
zyd1 is rescued by zydScer\UAS.cMa/Scer\GAL4Akap200-NP2222
(Melom and Littleton, 2013)
zyd1 is rescued by zydScer\UAS.cMa/Scer\GAL4nrv2.PS
(Melom and Littleton, 2013)
zyd1 is rescued by zydScer\UAS.cMa/Scer\GAL4repo
(Melom and Littleton, 2013)
zyd1 is rescued by zydScer\UAS.cMa/Scer\GAL4wun-NP1243
(Melom and Littleton, 2013)
Not rescued by
zyd1 is not rescued by Scer\GAL4elav-C155/zydScer\UAS.cMa
(Melom and Littleton, 2013)
zyd1 is not rescued by zydScer\UAS.cMa/Scer\GAL4alrm.PD
(Melom and Littleton, 2013)
Comments
Expression of zyd[Scer\UAS.cMa] under the control of Scer\GAL4[repo] rescues temperature-sensitives seizures in zyd[1] mutants, but expression under the control of Scer\GAL4[elav-C155] does not. Expression of zyd[Scer\UAS.cMa] under the control of either Scer\GAL4[Akap200-NP2222], Scer\GAL4[nrv2.PS] or Scer\GAL4[wun-NP1243] rescues temperature-sensitives seizures in zyd[1] mutants. Expression of zyd[Scer\UAS.cMa] under the control of Scer\GAL4[alrm.PD] fails to rescue temperature-sensitives seizures in zyd[1] mutants.
(Melom and Littleton, 2013)
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Discoverer
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Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym
zyd1
 
zydeco1
 
Name Synonym
zydeco
(Guan et al., 2011)
Secondary FlyBase IDs
hide References ( 2 )
Research paper
Melom and Littleton, 2013, J. Neurosci. 33(3): 1169--1178
Mutation of a NCKX Eliminates Glial Microdomain Calcium Oscillations and Enhances Seizure Susceptibility. [FBrf0220564]
Guan et al., 2011, Learn. Mem. 18(4): 191--206
Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. [FBrf0213277]