Allele Dmel\ckn^X.Q403stop

General Information
Symbol	Dmel\ckn^X.Q403stop	Species	D. melanogaster
Name		FlyBase ID	FBal0265798
Feature type	allele	Associated gene	Dmel\ckn

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Weng et al., 2011)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{GSV1}GS1205 (Weng et al., 2011)
Nature of the lesion	Statement Reference Amino acid replacement: Q403@. (Weng et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| embryonic stage (Weng et al., 2011) neuroanatomy defective \| embryonic stage (with Df(2R)BSC330) (Weng et al., 2011)
Phenotype Manifest In
	intersegmental nerve \| embryonic stage (Weng et al., 2011) intersegmental nerve \| embryonic stage (with Df(2R)BSC330) (Weng et al., 2011) intersegmental nerve branch ISNb of A1-7 \| embryonic stage (Weng et al., 2011) intersegmental nerve branch ISNb of A1-7 \| embryonic stage (with Df(2R)BSC330) (Weng et al., 2011)
Detailed Description
	Statement Reference ckn[X.Q403stop] homozygous or ckn[X.Q403stop]/Df(2R)BSC330 mutant embryos display consistent motor axon projection defects, exhibiting classic ISNb 'bypass' phenotypes, where ISNb axons fail to innervate the ventrolateral muscle field. These axons appear to defasciculate normally from the primary ISN branch at the exit junction, but fail to enter the ventral muscle field, instead bypassing their targets as they extend parallel to the primary ISN fascicle. Frequently, mis-targeted ISNb axons reach back from the dorsal edge of muscle 12 to innervate the ventrolateral muscle field. In the majority of affected nerves, ISNb axons are visible as a distinct fascicle next to the ISN. (Weng et al., 2011)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	ckn^X.Q403stop/Scer\GAL4^elav.PLu rescues ckn^Scer\UAS.cWa (Weng et al., 2011)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	ckn^X.Q403stop ckn^X (Weng et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Weng et al., 2011, J. Neurosci. 31(12): 4421--4433 The Cytoplasmic Adaptor Protein Caskin Mediates Lar Signal Transduction during Drosophila Motor Axon Guidance. [FBrf0213321]

Allele Dmel\cknX.Q403stop

Allele Dmel\ckn^X.Q403stop