Open Close
General Information
Symbol
Dmel\PGRP-LB500.dsRNA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0265814
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat of the first 500bp of PGRP-LB coding sequence.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Animals expressing PGRP-LB500.dsRNA.Scer\UAS under the control of Scer\GAL4da.G32 at 29[o]C show significant lethality. Adult escapers raised at 25[o]C are viable and show no visible difference to wild-type flies.

Animals expressing PGRP-LB500.dsRNA.Scer\UAS under the control of Scer\GAL4da.G32 exhibit reduced digestion of a "["[14]C"]"DAP-radio-labelled TCT dimer in both unchallenged and bacteria-challenged flies, indicating a significant decrease in hemolymph amidase activity.

Inactivation of PGRP-LB through expression of PGRP-LB500.dsRNA.Scer\UAS (under the control of Scer\GAL4da.G32) does not induce increased susceptibility to infection, as determined from fly survival rates following injection of E.carotovora.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
PGRP-LB500.dsRNA.Scer\UAS
PGRP-LB500.dsRNA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)