Open Close
General Information
Symbol
Dmel\caupUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0265897
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of caup which is tagged with a Tag:HA epitope.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of caupScer\UAS.T:Ivir\HA1 under the control of either Scer\GAL4nub.PU or Scer\GAL4ap-md544 (restricted to 16 hours prior the third instar larval stage onwards using Scer\GAL80ts.αTub84B) causes a significant reduction in the mitotic index in the wing disc. Cell size is not noticeably affected. Expression of caupScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4salm.EPv results in a reduction in the size of the central wing pouch of the wing disc and the adult wings. The adult wings show an altered venation pattern and wing margin notches. Enlarged cells are also seen in the Scer\GAL4salm.EPv-expressing domain. Apoptosis is increased compared with controls, especially in the central part of the Scer\GAL4salm.EPv-expressing domain. Reducing apoptosis using one copy of Df(3L)H99 (which removes the cell-death-inducing genes (rpr, hid and grim) does not modify the wing phenotypes.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Suppressed by
NOT suppressed by
Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference
Expression of Diap1Scer\UAS.cUa suppresses the apoptosis seen in the wing disc when caupScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4salm.EPv. The wing size, vein pattern and wing notching phenotypes are not modified by Diap1Scer\UAS.cUa. Expression of stgScer\UAS.cNa does not suppress the reduction in wing size and cell number seen when caupScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4salm.EPv. Expression of CycEScer\UAS.cLa suppresses the wing phenotypes seen when caupScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4salm.EPv. Expression of CycEScer\UAS.cLa suppresses the cell proliferation defects seen in the wing disc when caupScer\UAS.T:Ivir\HA1 is expressed under the control of either Scer\GAL4nub.PU or Scer\GAL4ap-md544 (restricted to 16 hours prior the third instar larval stage onwards using Scer\GAL80ts.αTub84B). Expression of Cdk2Scer\UAS.cUa does not suppress the wing phenotypes seen when caupScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4salm.EPv. Expression of dapScer\UAS.cUa enhances the wing phenotypes seen when caupScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4salm.EPv. Expression of agoHM04005 enhances the wing phenotypes seen when caupScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4salm.EPv. Expression of caupScer\UAS.T:Ivir\HA1 suppresses the eye disc overgrowth seen when ykiScer\UAS.cUa is expressed under the control of Scer\GAL4salm.EPv. This suppression is partially reverted upon co-expression of CycEScer\UAS.cLa.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
caupScer\UAS.T:Ivir\HA1
caupUAS.Tag:HA
Name Synonyms
Secondary FlyBase IDs
    References (2)