Allele Dmel\Rh5²

General Information
Symbol	Dmel\Rh5²	Species	D. melanogaster
Name		FlyBase ID	FBal0265961
Feature type	allele	Associated gene	Dmel\Rh5

Allele class
Mutagen	FLPase
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	FLPase (Yamaguchi et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{GT1}BG01539 (Yamaguchi et al., 2008)
Nature of the lesion	Statement Reference FLPase-mediated excision of P{GT1}BG01539, located 1.2kb upstream of Rh5, and P{EP}EP574, found downstream of the Rh5 ORF. (Yamaguchi et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	auditory perception defective \| adult stage (Senthilan et al., 2012) neurophysiology defective \| adult stage (Senthilan et al., 2012) phototaxis defective (Keene et al., 2011)
Phenotype Manifest In

Detailed Description
	Statement Reference Compound action potentials can be evoked by sound in the antennal nerve of mutant flies, but the sound particle velocities required to elicit the response is increased compared to wild type. The displacement response of the antenna over a range of sound particle velocities is linearised, indicating loss of mechanical amplification. (Senthilan et al., 2012) Light avoidance is completely lost in Rh5[2] mutants. (Keene et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference Rh5² has phototaxis defective phenotype, non-enhanceable by Rh6¹ (Keene et al., 2011)
NOT suppressed by
Statement Reference Rh5² has phototaxis defective phenotype, non-suppressible by Rh6¹ (Keene et al., 2011)
Other
Statement Reference Rh5², Rh6¹, sev¹ has optomotor response defective phenotype (Yamaguchi et al., 2008, Yamaguchi et al., 2008, Yamaguchi et al., 2008) Rh5², Rh6¹ has auditory perception defective \| adult stage phenotype (Senthilan et al., 2012) Rh5², Rh6¹ has neuroanatomy defective \| third instar larval stage phenotype (Yuan et al., 2011) Rh5², Rh6¹ has neurophysiology defective \| adult stage phenotype (Senthilan et al., 2012)
Phenotype Manifest In
Other
Statement Reference Rh5², Rh6¹ has dendrite \| third instar larval stage phenotype (Yuan et al., 2011) Rh5², Rh6¹ has LNv neuron \| third instar larval stage phenotype (Yuan et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference The sound threshold required to evoke a compound action potential in the antennal nerve in response in Rh5[2] Rh6[1] double mutants is almost twice as loud as required in single mutants. Ultrastructure of the Johnston's organ sensillum appears normal in the double mutant flies. (Senthilan et al., 2012) Rh5[2];Rh6[1] double mutants are completely blind, with light avoidance being completely lost at the larval stage. Rh5[2];Rh6[1] double mutants eclose at a similar rate as in wild-type. Despite Rh5[2];Rh6[1] double mutants having a decreased ability to degrade tim in response to light, they are still capable of proper circadian behavior. (Keene et al., 2011) Wild-type larvae display differences in their LN(v) dendrite length when exposed to constant darkness versus constant light. In contrast, such light induced changes are absent in Rh5[2], Rh6[1] double mutants. (Yuan et al., 2011) sev[1], Rh5[2], Rh6[1] triple mutant flies do not have R7 cells and do not express function R8 opsins, therefore colour vision should be completely abolished. However, the blue/green intensity-response curve for these flies appears indistinguishable from wild-type. (Yamaguchi et al., 2008)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Rh5² (Keene et al., 2011, Yamaguchi et al., 2008, Senthilan et al., 2012) rh5² (Vasiliauskas et al., 2011, Yuan et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Keene et al., 2011, J. Neurosci. 31(17): 6527--6534 Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment. [FBrf0213587] Vasiliauskas et al., 2011, Nature 479(7371): 108--112 Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors. [FBrf0216554] Yuan et al., 2011, Science 333(6048): 1458--1462 Light-induced structural and functional plasticity in Drosophila larval visual system. [FBrf0215276] Yamaguchi et al., 2008, Proc. Natl. Acad. Sci. U.S.A. 105(12): 4910--4915 Motion vision is independent of color in Drosophila. [FBrf0204275]

Allele Dmel\Rh52

Allele Dmel\Rh5²