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General Information
Symbol
Dmel\inc1
Species
D. melanogaster
Name
FlyBase ID
FBal0266013
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

257 bp deletion removes a transcription start of inc and upstream region to CG14795.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

257bp deletion between two divergently transcribed genes, CG14795 and inc. The transcription initiation site and 50bp of 5' untranslated region sequence of inc is removed by the deletion, while the 5' terminus and a small amount of upstream sequences of CG14795 remains intact. The level of both CG14795 and inc transcripts is reduced in the mutant.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

inc1 mutant adults sleep less (display reduced total amount of both daytime and nighttime sleep, along with short sleep bout length with increased bout number) than wild-type controls. Mutant third instar larvae show increased number of boutons on neuromuscular junction. Postsynaptic muscle recordings reveal altered synaptic transmission in inc1/incf00285 larvae: the amplitude of spontaneous miniature postsynaptic potentials is comparable to controls but their frequency is reduced, the amplitude of evoked potentials is decreased as is the quantal content.

These homozygotes are also short lived compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The sleep deficit (reduced total amount of both daytime and nighttime sleep, along with short sleep bout length with increased bout number) characteristic for inc1 mutant adults can be partially rescued by Scer\GAL4inc.PS-driven expression of either Mmus\Kctd2Scer\UAS.T:Hsap\MYC or Mmus\Kctd5Scer\UAS.T:Hsap\MYC (but not Mmus\Kctd17Scer\UAS.3.T:Hsap\MYC or Mmus\Kctd17Scer\UAS.2.T:Hsap\MYC) in the mutant background.

Complementation and Rescue Data
Comments

The sleep deficit (reduced total amount of both daytime and nighttime sleep, along with short sleep bout length with increased bout number) characteristic for inc1 mutant adults is rescued by expression of either incScer\UAS.T:Hsap\MYC or incScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4inc.PS.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (2)