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General Information
Symbol
Dmel\fraΔP3.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0266154
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of fra lacking the conserved cytoplasmic P3 motif.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ventral nerve cord axon bundles of stage 16 embryos overexpressing fraΔP3.Scer\UAS via Scer\GAL4ftz.ng do not display any incorrect midline crossing.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Commissure formation is restored in fra3/fra4 mutants expressing both fraΔP3.Scer\UAS and AblScer\UAS.cHa under the control of Scer\GAL4insc-Mz1407.

The frequency of crossovers across the midline in embryos expressing Rho1V14.Scer\UAS driven by Scer\GAL4ftz.ng is not increased by co-expression of fraΔP3.Scer\UAS.

Xenogenetic Interactions
Statement
Reference

In fra3/fra4 mutants expressing Scer\GAL4insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCRP210.Scer\UAS, expression of fraΔP3.Scer\UAS restores commissure formation in fra3/fra4 mutants. The frequency of fuzzy commissures is also significantly reduced.

fra3/fra4 significantly reduces the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCRP210.Scer\UAS when fraΔP3.Scer\UAS is co-expressed.

The frequency of neuronal crossover projections induced by Scer\GAL4ftz.ng-driven expression of Abl::Hsap\ABL1::Hsap\BCRP210.Scer\UAS is not significantly increased by co-expression of fraΔP3.Scer\UAS.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
fraΔP3.Scer\UAS
fraΔP3.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)