FB2025_01 , released February 20, 2025
Allele: Dmel\fraΔP3.UAS
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General Information
Symbol
Dmel\fraΔP3.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0266154
Feature type
allele
Associated gene
Dmel\fra
Associated Insertion(s)
Carried in Construct
P{UAS-fra.ΔP3}
Key Links
Transgenic product class
inframe_deletion
(Dorsten et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Dorsten et al., 2007)
Mutagen
in vitro construct
(Dorsten et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-fra.ΔP3}
Cytology
Description

UAS regulatory sequences drive expression of fra lacking the conserved cytoplasmic P3 motif.

(Dorsten et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fra
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ventral nerve cord axon bundles of stage 16 embryos overexpressing fraΔP3.Scer\UAS via Scer\GAL4ftz.ng do not display any incorrect midline crossing.

      (Dorsten et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Commissure formation is restored in fra3/fra4 mutants expressing both fraΔP3.Scer\UAS and AblScer\UAS.cHa under the control of Scer\GAL4insc-Mz1407.

      (Dorsten et al., 2010)

      The frequency of crossovers across the midline in embryos expressing Rho1V14.Scer\UAS driven by Scer\GAL4ftz.ng is not increased by co-expression of fraΔP3.Scer\UAS.

      (Dorsten et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference

      In fra3/fra4 mutants expressing Scer\GAL4insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCRP210.Scer\UAS, expression of fraΔP3.Scer\UAS restores commissure formation in fra3/fra4 mutants. The frequency of fuzzy commissures is also significantly reduced.

      fra3/fra4 significantly reduces the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCRP210.Scer\UAS when fraΔP3.Scer\UAS is co-expressed.

      (Dorsten et al., 2010)

      The frequency of neuronal crossover projections induced by Scer\GAL4ftz.ng-driven expression of Abl::Hsap\ABL1::Hsap\BCRP210.Scer\UAS is not significantly increased by co-expression of fraΔP3.Scer\UAS.

      (Dorsten et al., 2007)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fraΔP3.Scer\UAS
      fraΔP3.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)