FlyBase Allele Report: Dmel\Eaat1[SM1]

General Information

Symbol

Dmel\Eaat1^SM1

Species

D. melanogaster

Name

FlyBase ID

FBal0266202

Feature type

allele

Associated gene

Dmel\Eaat1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Stacey et al., 2010)

Progenitor genotype

P{EPgy2}Eaat1^EY20741

(Stacey et al., 2010)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 841bp deletion that removes the start codon and sequence encoding the first two transmembrane domains of Eaat1.

(Stacey et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | larval stage

(Stacey et al., 2010)

lethal - all die before end of larval stage

(Stacey et al., 2010)

lethal - all die before end of larval stage (with Df(2L)30A-C)

(Stacey et al., 2010)

lethal - all die before end of larval stage (with Eaat1^SM2)

(Stacey et al., 2010)

some die during larval stage

(Stacey et al., 2010)

some die during larval stage (with Df(2L)30A-C)

(Stacey et al., 2010)

some die during larval stage (with Eaat1^SM2)

(Stacey et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous, Eaat1^SM1/Eaat1^SM2 and Eaat1^SM1/Df(2L)30A-C larvae all die by 48 hours post-hatching.

Homozygous larvae have a dramatically reduced rate of full-body peristaltic contractions compared to controls.

(Stacey et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Eaat1^SM1

(Walker et al., 2013, Stacey et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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